Immunomechanobiology: Engineering the Activation and Function of Immune Cells with the Mechanical Signal of Fluid Shear Stress
Immunomechanobiology, the study of how physical forces influence the behavior and
function of immune cells, is a rapidly growing area of research. It is becoming increasingly …
function of immune cells, is a rapidly growing area of research. It is becoming increasingly …
Inflammatory Signaling via PEIZO1 Engages and Enhances the LPS-Mediated Apoptosis during Clinical Mastitis
J Wang, M Li, W Wu, HJ Zhang, Y Yang… - Journal of Agricultural …, 2024 - ACS Publications
Bovine clinical mastitis is characterized by inflammation and immune responses, with
apoptosis of mammary epithelial cells as a cellular reaction to infection. PIEZO1, identified …
apoptosis of mammary epithelial cells as a cellular reaction to infection. PIEZO1, identified …
Sprayable inflammasome-inhibiting lipid nanorods in a polymeric scaffold for psoriasis therapy
Localized delivery of inflammasome inhibitors in phagocytic macrophages could be
promising for psoriasis treatment. The present work demonstrates the development of non …
promising for psoriasis treatment. The present work demonstrates the development of non …
Role of mechanosensitive channel Piezo1 protein in intestinal inflammation regulation: A potential target
Q Jiang, Z Li, D Dang, J Wei, H Wu - The FASEB Journal, 2024 - Wiley Online Library
The intestine is a hollow tract that primarily transports and digests food. It often encounters
mechanical forces and exotic threats, resulting in increased intestinal inflammation attributed …
mechanical forces and exotic threats, resulting in increased intestinal inflammation attributed …
Extracellular vesicles from mechanical loading stimulated-macrophage favor fracture healing through targeting Adrb2 of osteoblast
H Zhao, W Liu, P Wang, S Zhang, X Xing, Z Yan… - Chemical Engineering …, 2024 - Elsevier
Appropriate mechanical loading (ML) accelerates fracture healing. Macrophages, being the
primary mechanosensitive immune cells, play a pivotal role in the regulation of bone …
primary mechanosensitive immune cells, play a pivotal role in the regulation of bone …
[HTML][HTML] Increased expression levels of PIEZO1 in visceral adipose tissue in obesity and type 2 diabetes are triggered by mechanical forces and are associated with …
V Catalán, J Gómez-Ambrosi, B Ramírez… - Molecular …, 2024 - pmc.ncbi.nlm.nih.gov
Background PIEZO1 has emerged as a mechanoreceptor linked with adipogenesis, adipose
tissue (AT) inflammation and insulin resistance. We aimed to determine the impact of obesity …
tissue (AT) inflammation and insulin resistance. We aimed to determine the impact of obesity …
[HTML][HTML] Mechano-immunological checkpoints: An emerging strategy for investigation and evaluation of disease and therapeutics
W Hu, C Wu, J Long, Z Zeng - Smart Materials in Medicine, 2024 - Elsevier
Over the past decades, increasing evidence has indicated that multiple mechanical signals
with different magnitude and pattern, including fluid flow-derived shear stress, topology of …
with different magnitude and pattern, including fluid flow-derived shear stress, topology of …
Hypericum sampsonii ameliorates radiodermatitis by inhibiting NLRP3 inflammasome activation
J Liao, Z Liu, S Wu - Skin Research and Technology, 2024 - Wiley Online Library
Background Radiodermatitis (RD) is an inflammatory lesion of skin mucosa caused by
radiation, which causes itching and pain in patients' skin. Hypericum sampsonii has an anti …
radiation, which causes itching and pain in patients' skin. Hypericum sampsonii has an anti …