Substance P is a peptide mainly secreted by neurons and is involved in many biological
processes, including nociception and inflammation. Animal models have provided insights …

Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by
cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms …

The diffuse neuroendocrine system consists of specialised endocrine cells and peptidergic
nerves and is present in all organs of the body. Substance P (SP) is secreted by nerves and …

1. Introduction......................................... II. Anatomy and physiology................................ A. The
peripheral apparatus............................. Fiber composition of muscle nerves …

Osteoarthritis (OA) is the most common form of joint disease and a major cause of pain and
disability in the adult population. Interestingly, there are patients with symptomatic OA …

Review Article Afferent and spinal mechanisms of joint pain Page 1 Pain, 55 (1993) 5-54 0
1993 Elsevier Science Publishers BV All rights reserved 0304-3959/93/$06.00 5 PAIN …

This article described research aimed at testing the hypothesis that tissue remodeling during
orthodontic tooth movement is modulated, at least in part, by factors derived from the …

Two groups of mediators, the neuropeptides substance P and K and the monocyte-derived
cytokines, interact in the neural regulation of immunological and inflammatory responses …

Peptides, as neurotransmitters, neuromodulators, and hormones, influence a multitude of
physiological processes by signal transduction mediated through receptors. In addition …

The peripheral nervous system is critically involved in bone metabolism, osteogenesis, and
bone remodeling. Nerve fibers of sympathetic and sensory origin innervate synovial tissue …