The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …

Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …

Macrophages are versatile and heterogeneous innate immune cells undertaking central
functions in balancing immune responses and tissue repair to maintain homeostasis. This …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Lipid peroxidation–dependent ferroptosis has become an emerging strategy for tumor
therapy. However, current strategies not only selectively induce ferroptosis in malignant cells …

The pandemic of COVID-19 is the biggest public health crisis in 21 st Century. Besides the
acute symptoms after infection, patients and society are also being challenged by the long …

The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically
associated with other chronic inflammation-driven disorders, including cardio-metabolic …

Trained immunity is a functional state of the innate immune response and is characterized
by long-term epigenetic reprogramming of innate immune cells. This concept originated in …