Top-down feedback in cortex is critical for guiding sensory processing, which has
prominently been formalized in the theory of hierarchical predictive coding (hPC). However …

Research on predictive processing models has focused largely on two specific algorithmic
theories: Predictive Coding for perception and Active Inference for decision-making. While …

Western diets rich in fat and sugar promote excess calorie intake and weight gain; however,
the underlying mechanisms are unclear. Despite a well-documented association between …

Psychiatry faces fundamental challenges with regard to mechanistically guided differential
diagnosis, as well as prediction of clinical trajectories and treatment response of individual …

Survival under selective pressure is driven by the ability of our brain to use sensory
information to our advantage to control physiological needs. To that end, neural circuits …

The ability to learn about other people is crucial for human social functioning. Dopamine has
been proposed to regulate the precision of beliefs, but direct behavioural evidence of this is …

Bayesian theories of autism spectrum disorders (ASD) suggest that atypical predictive
mechanisms could underlie the autistic symptomatology, but little is known about their …

For the past decade, ketamine, an N-methyl-D-aspartate receptor (NMDAr) antagonist, has
been considered a promising treatment for major depressive disorder (MDD). Unlike the …

Animals abstract compact representations of a task's structure, which supports accelerated
learning and flexible behavior. Whether and how such abstracted representations may be …

In this study, we examined the relationship between physiological encoding of surprise and
the learning of anticipatory eye movements. Active inference portrays perception and action …