Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) are a
recent addition to the lipids accumulated in obesity and have emerged as important …

Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …

The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Type 2 diabetes mellitus (T2DM) is a systemic disease characterized by hyperglycemia,
hyperlipidemia, and organismic insulin resistance. This pathological shift in both circulating …

Type 2 diabetes is caused by chronic insulin resistance and progressive decline in beta-cell
function. Optimal beta-cell function and mass is essential for glucose homeostasis and beta …

Nowadays, there are some molecules that have shown over the years a high capacity to act
against relevant pathologies such as cardiovascular disease, neurodegenerative disorders …