There is no simple model of the plasma membrane organization

J Bernardino de la Serna, GJ Schütz… - Frontiers in cell and …, 2016 - frontiersin.org
Ever since technologies enabled the characterization of eukaryotic plasma membranes,
heterogeneities in the distributions of its constituents were observed. Over the years this led …

Lessons in fluctuation correlation spectroscopy

MA Digman, E Gratton - Annual review of physical chemistry, 2011 - annualreviews.org
Molecular diffusion and transport processes are fundamental in physical, chemical, and
biological systems. Current approaches to measuring molecular transport in cells and …

Phase separation drives heterochromatin domain formation

AR Strom, AV Emelyanov, M Mir, DV Fyodorov… - Nature, 2017 - nature.com
Constitutive heterochromatin is an important component of eukaryotic genomes that has
essential roles in nuclear architecture, DNA repair and genome stability, and silencing of …

Voluntary rewards mediate the evolution of pool punishment for maintaining public goods in large populations

T Sasaki, S Uchida, X Chen - Scientific reports, 2015 - nature.com
Punishment is a popular tool when governing commons in situations where free riders
would otherwise take over. It is well known that sanctioning systems, such as the police and …

PAM: a framework for integrated analysis of imaging, single-molecule, and ensemble fluorescence data

W Schrimpf, A Barth, J Hendrix, DC Lamb - Biophysical journal, 2018 - cell.com
Fluorescence microscopy and spectroscopy data hold a wealth of information on the
investigated molecules, structures, or organisms. Nowadays, the same fluorescence data set …

Actomyosin-generated tension controls the molecular kinetics of focal adhesions

H Wolfenson, A Bershadsky, YI Henis… - Journal of cell …, 2011 - journals.biologists.com
Focal adhesions (FAs) have key roles in the interaction of cells with the extracellular matrix
(ECM) and in adhesion-mediated signaling. These dynamic, multi-protein structures sense …

Membrane microdomains, rafts, and detergent-resistant membranes in plants and fungi

J Malinsky, M Opekarová, G Grossmann… - Annual review of …, 2013 - annualreviews.org
The existence of specialized microdomains in plasma membranes, postulated for almost 25
years, has been popularized by the concept of lipid or membrane rafts. The idea that …

Noncanonical GPCR signaling arising from a PTH receptor–arrestin–Gβγ complex

VL Wehbi, HP Stevenson… - Proceedings of the …, 2013 - National Acad Sciences
G protein-coupled receptors (GPCRs) participate in ubiquitous transmembrane signal
transduction processes by activating heterotrimeric G proteins. In the current “canonical” …

[HTML][HTML] Particle tracking of nanoparticles in soft matter

KA Rose, M Molaei, MJ Boyle, D Lee… - Journal of Applied …, 2020 - pubs.aip.org
Recent advances in optical microscopy instrumentation and processing techniques have led
to imaging that both breaks the diffraction barrier and enables sub-pixel resolution. This …

Raster image correlation spectroscopy in live cells

MJ Rossow, JM Sasaki, MA Digman, E Gratton - Nature protocols, 2010 - nature.com
Raster image correlation spectroscopy (RICS) is a noninvasive technique to detect and
quantify events in a live cell, including concentration of molecules and diffusion coefficients …