Preclinical models that can accurately predict outcomes in the clinic are much sought after in
the field of cancer drug discovery and development. Existing models such as organoids and …

Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …

Over the past 15 years, the field of oncology research has witnessed significant progress in
the development of new cell culture models, such as tumor-on-chip (ToC) systems. In this …

Drug resistance has profoundly limited the success of cancer treatment, driving relapse,
metastasis, and mortality. Nearly all anticancer drugs and even novel immunotherapies …

Tumor evolution is the accumulation of various tumor cell behaviors from tumorigenesis to
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …

The approval of anticancer therapeutic strategies is still slowed down by the lack of models
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …

Rationale: Current therapies for metastatic osseous disease frequently fail to provide a
durable treatment response. To date, there are only limited therapeutic options for metastatic …

Capillaries are small microscopic channels found in nature predominantly. These flow blood
in animals and food, water and nutritions in plants. Mimicking these capillaries scientist …

Oesophageal cancer (OC) is an inflammation-associated malignancy linked to gastro-
oesophageal reflux disease, obesity and tobacco use. Knowledge of the microenvironment …

A key reason for the persistently grim statistics associated with metastatic ovarian cancer is
resistance to conventional agents, including platinum-based chemotherapies. A major …