Patterns of synaptic connections in the visual system are remarkably precise. These
connections dictate the receptive field properties of individual visual neurons and ultimately …

In the central nervous system, most excitatory synapses occur on dendritic spines, which are
small protrusions from the dendritic tree. In the mature cortex and hippocampus, dendritic …

Our understanding of how mammalian sensory circuits are organized and develop has long
been hindered by the lack of genetic markers of neurons with discrete functions. Here, we …

Although it is widely accepted that molecular mechanisms play an important role in the initial
establishment of retinotopic maps, it has also long been argued that activity-dependent …

A central question in brain evolution is how species-typical behaviors, and the neural
function-structure mappings supporting them, can be acquired and inherited. Advocates of …

The dorsal horn of the spinal cord in the newborn rat is characterized by large cutaneous
mechanoreceptive fields, a predominance of A‐fibre synaptic inputs and diffuse primary …

The consequences of deafness on the central auditory nervous system have been examined
at many levels, from molecular to functional. However, there has never been a direct and …

NMDA-type glutamate receptors (NMDARs) play a central role in the rapid regulation of
synaptic transmission, but their contribution to the long-term stabilization of glutamatergic …

Although the organization of neuronal circuitry is shaped by activity patterns, the capacity to
modify and/or optimize the structure and function of whole projection pathways using …

The development of orderly topographic maps in the central nervous system (CNS) results
from a collaboration of chemoaffinity cues that establish the coarse organization of the …