Small-cell lung cancer (SCLC) represents about 15% of all lung cancers and is marked by
an exceptionally high proliferative rate, strong predilection for early metastasis and poor …

Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis,,.
We sequenced 29 SCLC exomes, 2 genomes and 15 transcriptomes and found an …

Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …

Abstract Machine learning (ML) is being ubiquitously incorporated into everyday products
such as Internet search, email spam filters, product recommendations, image classification …

Proteins regulate many cellular functions and analyzing the presence and abundance of
proteins in biological samples are central focuses in proteomics. The discovery and …

Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer
treatment and carries a five-year survival rate of only 8%. Inhibition of oncogenic KRAS …

Evidence accumulates that the transcription factor nuclear factor E2-related factor 2 (Nrf2)
has an essential role in cancer development and chemoresistance, thus pointing to its …

Epithelial-to-mesenchymal transition (EMT) is a key process associated with tumor
progression and metastasis. To define molecular features associated with EMT states, we …

The immunoproteasome plays a key role in generation of HLA peptides for T cell-mediated
immunity. Integrative genomic and proteomic analysis of non-small cell lung carcinoma …