After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …

Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction …

The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple
cardiac cell lineages during embryonic development and provides signals that are essential …

An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …

Tissue-like structures from human pluripotent stem cells containing multiple cell types are
transforming our ability to model and understand human development and disease. Here we …

Advances in our understanding of cardiovascular development have provided a roadmap for
the directed differentiation of human pluripotent stem cells (hPSCs) to the major cell types …

The epicardium, the outer epithelial layer that covers the myocardium, derives from a
transient organ known as pro-epicardium, crucial during heart organogenesis. The pro …

Aging poses a major risk factor for cardiovascular diseases, the leading cause of death in
the aged population. However, the cell type-specific changes underlying cardiac aging are …

In the last decade, the generation of cardiac disease models based on human-induced
pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to …