Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans

S Kullmann, M Heni, M Hallschmid… - Physiological …, 2016 - journals.physiology.org
Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …

Impaired insulin action in the human brain: causes and metabolic consequences

M Heni, S Kullmann, H Preissl, A Fritsche… - Nature Reviews …, 2015 - nature.com
Over the past few years, evidence has accumulated that the human brain is an insulin-
sensitive organ. Insulin regulates activity in a limited number of specific brain areas that are …

Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways

KA Page, O Chan, J Arora, R Belfort-DeAguiar… - Jama, 2013 - jamanetwork.com
Importance Increases in fructose consumption have paralleled the increasing prevalence of
obesity, and high-fructose diets are thought to promote weight gain and insulin resistance …

The human sexual response cycle: brain imaging evidence linking sex to other pleasures

JR Georgiadis, ML Kringelbach - Progress in neurobiology, 2012 - Elsevier
Sexual behavior is critical to species survival, yet comparatively little is known about the
neural mechanisms in the human brain. Here we systematically review the existing human …

Comparing apples and oranges: using reward-specific and reward-general subjective value representation in the brain

DJ Levy, PW Glimcher - Journal of Neuroscience, 2011 - Soc Neuroscience
The ability of human subjects to choose between disparate kinds of rewards suggests that
the neural circuits for valuing different reward types must converge. Economic theory …

[HTML][HTML] Neural responses to visual food cues according to weight status: a systematic review of functional magnetic resonance imaging studies

KM Pursey, P Stanwell, RJ Callister, K Brain… - Frontiers in …, 2014 - frontiersin.org
Emerging evidence from recent neuroimaging studies suggests that specific food-related
behaviors contribute to the development of obesity. The aim of this review was to report the …

The functional human neuroanatomy of food pleasure cycles

ML Kringelbach, A Stein, TJ van Hartevelt - Physiology & behavior, 2012 - Elsevier
Food ensures our survival and is a potential source of pleasure and general well-being. In
order to survive, the human brain is required to optimize the resource allocation such that …

Children exposed to maternal obesity or gestational diabetes mellitus during early fetal development have hypothalamic alterations that predict future weight gain

KA Page, S Luo, X Wang, T Chow, J Alves… - Diabetes …, 2019 - Am Diabetes Assoc
OBJECTIVE Exposure in utero to maternal obesity or gestational diabetes mellitus (GDM) is
linked to a high risk for obesity in offspring. Animal studies suggest that these exposures …

Resting‐state functional connectivity of the human hypothalamus

S Kullmann, M Heni, K Linder, S Zipfel… - Human brain …, 2014 - Wiley Online Library
The hypothalamus is of enormous importance for multiple bodily functions such as energy
homeostasis. Especially, rodent studies have greatly contributed to our understanding how …

[HTML][HTML] Functional magnetic resonance imaging of human hypothalamic responses to sweet taste and calories

PAM Smeets, C de Graaf, A Stafleu… - The American journal of …, 2005 - Elsevier
Background: Evidence exists that beverages do not trigger appropriate anticipatory
physiologic responses, such as cephalic phase insulin release. Therefore, it is of interest to …