Abstract Alzheimer's disease (AD), the most common cause of age-dependent dementia, is
one of the most significant healthcare problems worldwide. Aggravating this situation, drugs …

J. Neurochem.(2012) 120 (Suppl. 1), 71–83. Abstract β‐Secretase (memapsin 2; BACE‐1) is
the first protease in the processing of amyloid precursor protein leading to the production of …

Alzheimer's disease (AD) is a fatal progressive neurodegenerative disorder characterized by
increasing loss in memory, cognition, and function of daily living. Among the many …

J. Neurochem.(2011) 117, 359–374. Abstract Current evidence suggests that Alzheimer's
disease (AD) is a multi‐factorial disease that starts with accumulation of multiple proteins …

The seed embryo of Nelumbo nucifera Gaertn. is a famous traditional Chinese medicine and
food which is considered conducive to the prevention of Alzheimer's disease (AD). In this …

BACE1, a membrane-bound aspartyl protease that is implicated in Alzheimer's disease, is
the first protease to cut the amyloid precursor protein resulting in the generation of amyloid-β …

The lethal factor of Bacillus anthracis is a major factor for lethality of anthrax infection by this
bacterium. With the aid of the protective antigen, lethal factor gains excess to the cell cytosol …

Aim: To identify a small molecule L655, 240 as a novel β-secretase (BACE1) inhibitor and to
investigate its effects on β-amyloid (Aβ) generation in vitro. Methods: Fluorescence …

Abstract Memapsin 2 (BACE1, β-secretase), a membrane aspartic protease, functions in the
cleavage of the type I transmembrane protein, β-amyloid precursor protein (APP), leading to …

Aging is a complex biological process marked by a progressive decline in physiological
functions and structural integrity at the cellular and tissue levels, driven by hallmarks such as …