The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

Abstract Interleukin-22 (IL-22) is an IL-10 family cytokine produced by T cells and innate
lymphoid cells. The IL-22 signaling pathway orchestrates mucosal immune defense and …

The melanoma differentiation-associated gene-7 (mda-7; approved gene symbol IL24) is a
tumor suppressor gene whose expression induces selective apoptosis in tumor cells. To …

Background Numerous studies have shown that long non-coding RNAs (lncRNAs) behave
as a novel class of transcript during multiple cancer processes, such as cell proliferation …

The mda-7 gene (approved gene symbol IL24) is a novel tumor suppressor gene with tumor-
apoptotic and immune-activating properties. We completed a Phase I dose-escalation …

“Differentiation therapy” provides a unique and potentially effective, less toxic treatment
paradigm for cancer. Moreover, combining “differentiation therapy” with molecular …

Cancer is a complex progressive multistep disorder that results from the accumulation of
genetic and epigenetic abnormalities, which lead to the transformation of normal cells into …

The melanoma differentiation associated gene-7 (mda-7) cDNA was isolated by virtue of
being induced during melanoma differentiation. Initial gene transfer studies convincingly …

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24) is a unique
member of the IL-10 gene family that displays nearly ubiquitous cancer-specific toxicity, with …

Summary Interleukin 24 (IL‐24) is a new member of the IL‐10 family of cytokines and it
signals through two heterodimeric receptors: IL‐20R1/IL‐20R2 and IL‐22R1/IL‐20R2. Upon …