In adult mammals, hematopoietic stem cells (HSCs) are defined by their abilities to self‐
renew and to differentiate to form all blood cell lineages. These rare multipotent cells occupy …

Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during
embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and …

Mesenchymal stem cells (MSCs) are typically defined by their in vitro characteristics, and as
a consequence the in vivo identity of MSCs and their niches are poorly understood. To …

The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …

The zinc-finger transcription factor GATA-3 has received much attention as a master
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

Hematopoietic stem cells (HSCs) are the rare cells responsible for the lifelong curative
effects of hematopoietic cell (HC) transplantation. The demand for clinical-grade HSCs has …

Hematopoietic stem cells (HSCs) develop from a specialized subpopulation of endothelial
cells known as hemogenic endothelium (HE). Although the HE origin of HSCs is now well …

While it is well known from numerous epidemiologic investigations that social determinants
(socioeconomic, environmental, and psychosocial factors exposed to over the life-course) …