Highlights•AAV is a non-pathogenic virus, and recombinant AAV vectors have proven to be
highly efficient for gene delivery to a wide variety of cell types, tissue, and organs in small …

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic
fibrosis transmembrane conductance regulator (CFTR) gene that encodes a cAMP …

Adeno-associated virus serotype 4 (AAV4) and AAV5 have different tropisms compared to
AAV2 and to each other. We recently reported that α2-3 sialic acid is required for AAV5 …

Adenovirus binds its receptor (CAR), enters cells, and replicates. It must then escape to the
environment to infect a new host. We found that following infection, human airway epithelia …

The restriction of viral receptors and coreceptors to the basolateral surface of airway
epithelial cells has been blamed for the inefficient transfer of viral vectors to the apical …

Gene transfer vectors based on the human adeno-associated virus serotype 2 (AAV-2) have
been developed and tested in pre-clinical studies for almost 20 years, and are currently …

Abstract The Adeno-associated viruses (AAVs) are not associated with any diseases, and
their ability to package non-genomic DNA and to transduce different cell/tissue populations …

Recombinant adeno-associated viruses (AAV) are promising gene therapy vectors.
Whereas AAV serotype 2-mediated gene transfer to muscle has partially replaced factor IX …

Cystic fibrosis (CF) is a life-threatening autosomal-recessive disease caused by mutations in
a single gene encoding cystic fibrosis transmembrane conductance regulator (CFTR). CF …

Respiratory syncytial virus (RSV) is a major cause of severe pneumonia and bronchiolitis in
infants and young children, and causes disease throughout life. Understanding the biology …