Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Adult stem cells sustain tissue homeostasis and regeneration; their functional decline is
often linked to aging, which is characterized by the progressive loss of physiological …

Muscle regeneration is the result of the concerted action of multiple cell types driven by the
temporarily controlled phenotype switches of infiltrating monocyte–derived macrophages …

Background Impaired muscle regeneration and increased muscle fibrosis are observed in
aged muscle accompanied by progressive loss of muscle mass (sarcopenia). However, the …

Skeletal muscle regeneration that follows acute injury is strongly influenced by interactions
with immune cells that invade and proliferate in the damaged tissue. Discoveries over the …

Impaired recovery of aged muscle following a disuse event is an unresolved issue facing the
older adult population. Although investigations in young animals have suggested that rapid …

Specialized pro‐resolving mediators actively limit inflammation and support tissue
regeneration, but their role in age‐related muscle dysfunction has not been explored. We …

Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant
changes in its resident stem cells (ie, satellite cells, SCs), differentiated cells (ie, myofibers) …

Background Chronic limb-threatening ischemia (CLTI), a severe manifestation of peripheral
arterial disease (PAD), is associated with a 1-year limb amputation rate of approximately 15 …

Macrophages are critical for regulation of inflammatory response during endotoxemia and
septic shock. However, the mediators underlying their regulatory function remain obscure …