Non-coding RNAs as drug targets

M Matsui, DR Corey - Nature reviews Drug discovery, 2017 - nature.com
Most of the human genome encodes RNAs that do not code for proteins. These non-coding
RNAs (ncRNAs) may affect normal gene expression and disease progression, making them …

Resolution of inflammation: a new therapeutic frontier

JN Fullerton, DW Gilroy - Nature reviews Drug discovery, 2016 - nature.com
Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

MicroRNA as an important target for anticancer drug development

Z Fu, L Wang, S Li, F Chen, KKW Au-Yeung… - Frontiers in …, 2021 - frontiersin.org
Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …

MicroRNA-based therapeutics in central nervous system injuries

P Sun, DZ Liu, GC Jickling… - Journal of Cerebral …, 2018 - journals.sagepub.com
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

MicroRNA mimics or inhibitors as antiviral therapeutic approaches against COVID-19

C Hum, J Loiselle, N Ahmed, TA Shaw, C Toudic… - Drugs, 2021 - Springer
Coronaviruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
responsible for the coronavirus disease 2019 (COVID-19) pandemic, present a significant …

Gene therapy to enhance angiogenesis in chronic wounds

E Shaabani, M Sharifiaghdam, R Faridi-Majidi… - … Therapy-Nucleic Acids, 2022 - cell.com
Skin injuries and chronic non-healing wounds are one of the major global burdens on the
healthcare systems worldwide due to their difficult-to-treat nature, associated co-morbidities …

MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets

M Kimura, S Kothari, W Gohir… - Clinical microbiology …, 2023 - Am Soc Microbiol
MicroRNAs (miRNAs) are conserved, short, non-coding RNAs that play a crucial role in the
post-transcriptional regulation of gene expression. They have been implicated in the …

Machine learning integrated ensemble of feature selection methods followed by survival analysis for predicting breast cancer subtype specific miRNA biomarkers

JP Sarkar, I Saha, A Sarkar, U Maulik - Computers in Biology and Medicine, 2021 - Elsevier
Breast cancer is the second leading cancer type among females. In this regard, it is found
that microRNAs play an important role by regulating the gene expressions at the post …

Plant-derived edible nanoparticles and miRNAs: emerging frontier for therapeutics and targeted drug-delivery

S Iravani, RS Varma - ACS Sustainable Chemistry & Engineering, 2019 - ACS Publications
Rigorous and timely studies have been conducted to develop natural and green
nanomedicines wherein plant-derived edible nanoparticles (PDENs) have a great potential …

Graph convolution for predicting associations between miRNA and drug resistance

Y Huang, P Hu, KCC Chan, ZH You - Bioinformatics, 2020 - academic.oup.com
Motivation MicroRNA (miRNA) therapeutics is becoming increasingly important. However,
aberrant expression of miRNAs is known to cause drug resistance and can become an …