The barrier surfaces of the gastrointestinal tract are in constant contact with various
microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the …

The study of the tumor microenvironment (TME) has become an important part of colorectal
cancer (CRC) research. Indeed, it is now accepted that the invasive character of a primary …

Microtubule-associated serine-threonine kinase-like (MASTL) has recently been identified
as an oncogenic kinase given its overexpression in numerous cancers. Our group has …

Intestinal homeostasis and the maintenance of the intestinal epithelial barrier are essential
components of host defense during gastrointestinal Salmonella Typhimurium infection. Both …

Background A new strategy, particularly a novel combination, for immunotherapy in
microsatellite stable metastatic colorectal cancer (mCRC) treatment needs to be formulated …

Inflammation is the main driver of the tumor initiation and progression in colitis-associated
colorectal cancer (CAC). Recent findings have indicated that the signal transducer and …

Simple Summary Colorectal cancer (CRC) is the second most common cause of cancer-
related death worldwide. While the exact causes and prognosis of CRC are complex …

Inflammatory responses of the intestinal epithelial barrier in patients with Crohn's disease
(CD), a chronic inflammatory bowel disease (IBD), are associated with gut microbial …

Signal transducer and activator of transcription 1 (STAT1) acts as a tumor suppressor
molecule in colitis-associated colorectal cancer (CAC), particularly during the very early …

Cytokines are the crucial signaling proteins that mediate the crosstalks between the cells of
tumor microenvironment (TME). Interferon-1 (IFN-1) are the important cytokines that are …