Why repetitive DNA is essential to genome function
JA Shapiro, R von Sternberg - Biological Reviews, 2005 - cambridge.org
There are clear theoretical reasons and many well-documented examples which show that
repetitive DNA is essential for genome function. Generic repeated signals in the DNA are …
repetitive DNA is essential for genome function. Generic repeated signals in the DNA are …
The eukaryotic genome: a system regulated at different hierarchical levels
R Van Driel, PF Fransz… - Journal of cell …, 2003 - journals.biologists.com
Eukaryotic gene expression can be viewed within a conceptual framework in which
regulatory mechanisms are integrated at three hierarchical levels. The first is the sequence …
regulatory mechanisms are integrated at three hierarchical levels. The first is the sequence …
Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2
LK Linares, R Kiernan, R Triboulet… - Nature cell …, 2007 - nature.com
The p300–CBP-associated factor (PCAF) is a histone acetyltransferase (HAT) involved in
the reversible acetylation of various transcriptional regulators, including the tumour …
the reversible acetylation of various transcriptional regulators, including the tumour …
Protein: protein interactions and the pairing of boundary elements in vivo
J Blanton, M Gaszner, P Schedl - Genes & development, 2003 - genesdev.cshlp.org
Although it is now well-established that boundary elements/insulators function to subdivide
eukaryotic chromosomes into autonomous regulatory domains, the underlying mechanisms …
eukaryotic chromosomes into autonomous regulatory domains, the underlying mechanisms …
Genomic insulators: connecting properties to mechanism
EJ Kuhn, PK Geyer - Current opinion in cell biology, 2003 - Elsevier
Insulators are regulatory elements that establish independent domains of transcriptional
activity within eukaryotic genomes. Insulators possess two properties: an anti-enhancer …
activity within eukaryotic genomes. Insulators possess two properties: an anti-enhancer …
Polytene chromosomes: 70 years of genetic research.
Polytene chromosomes were described in 1881 and since 1934 they have served as an
outstanding model for a variety of genetic experiments. Using the polytene chromosomes …
outstanding model for a variety of genetic experiments. Using the polytene chromosomes …
BEAF Regulates Cell-Cycle Genes through the Controlled Deposition of H3K9 Methylation Marks into Its Conserved Dual-Core Binding Sites
E Emberly, R Blattes, B Schuettengruber… - PLoS …, 2008 - journals.plos.org
Chromatin insulators/boundary elements share the ability to insulate a transgene from its
chromosomal context by blocking promiscuous enhancer–promoter interactions and …
chromosomal context by blocking promiscuous enhancer–promoter interactions and …
The Drosophila boundary element-associated factors BEAF-32A and BEAF-32B affect chromatin structure
MK Gilbert, YY Tan, CM Hart - Genetics, 2006 - academic.oup.com
Binding sites for the Drosophila b oundary e lement-a ssociated f actors BEAF-32A and-32B
are required for the insulator activity of the scs′ insulator. BEAF binds to hundreds of sites …
are required for the insulator activity of the scs′ insulator. BEAF binds to hundreds of sites …
Characterization of BEAF Mutations Isolated by Homologous Recombination in Drosophila
Abstract The Drosophila BEAF-32A and BEAF-32B proteins bind to the scs′ insulator and
to hundreds of other sites on Drosophila chromosomes. These two proteins are encoded by …
to hundreds of other sites on Drosophila chromosomes. These two proteins are encoded by …
On the roles of repetitive DNA elements in the context of a unified genomic‐epigenetic system
RV Sternberg - Annals of the New York Academy of Sciences, 2002 - Wiley Online Library
Repetitive DNA sequences comprise a substantial portion of most eukaryotic and some
prokaryotic chromosomes. Despite nearly forty years of research, the functions of various …
prokaryotic chromosomes. Despite nearly forty years of research, the functions of various …