There are clear theoretical reasons and many well-documented examples which show that
repetitive DNA is essential for genome function. Generic repeated signals in the DNA are …

Eukaryotic gene expression can be viewed within a conceptual framework in which
regulatory mechanisms are integrated at three hierarchical levels. The first is the sequence …

The p300–CBP-associated factor (PCAF) is a histone acetyltransferase (HAT) involved in
the reversible acetylation of various transcriptional regulators, including the tumour …

Although it is now well-established that boundary elements/insulators function to subdivide
eukaryotic chromosomes into autonomous regulatory domains, the underlying mechanisms …

Insulators are regulatory elements that establish independent domains of transcriptional
activity within eukaryotic genomes. Insulators possess two properties: an anti-enhancer …

Polytene chromosomes were described in 1881 and since 1934 they have served as an
outstanding model for a variety of genetic experiments. Using the polytene chromosomes …

Chromatin insulators/boundary elements share the ability to insulate a transgene from its
chromosomal context by blocking promiscuous enhancer–promoter interactions and …

Binding sites for the Drosophila b oundary e lement-a ssociated f actors BEAF-32A and-32B
are required for the insulator activity of the scs′ insulator. BEAF binds to hundreds of sites …

Abstract The Drosophila BEAF-32A and BEAF-32B proteins bind to the scs′ insulator and
to hundreds of other sites on Drosophila chromosomes. These two proteins are encoded by …

Repetitive DNA sequences comprise a substantial portion of most eukaryotic and some
prokaryotic chromosomes. Despite nearly forty years of research, the functions of various …