Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods
S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …
Biocatalysis making waves in organic chemistry
U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …
biocatalysis has developed, and in doing so changed our perception of what organic …
Power of biocatalysis for organic synthesis
CK Winkler, JH Schrittwieser, W Kroutil - ACS central science, 2021 - ACS Publications
Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …
tool in organic synthesis, which is also frequently applied in industry. The generally high …
Broadening the scope of biocatalysis in sustainable organic synthesis
RA Sheldon, D Brady - ChemSusChem, 2019 - Wiley Online Library
This Review is aimed at synthetic organic chemists who may be familiar with organometallic
catalysis but have no experience with biocatalysis, and seeks to provide an answer to the …
catalysis but have no experience with biocatalysis, and seeks to provide an answer to the …
Asymmetric carbohydroxylation of alkenes using photoenzymatic catalysis
Alkene difunctionalizations enable the synthesis of structurally elaborated products from
simple and ubiquitous starting materials in a single chemical step. Carbohydroxylations of …
simple and ubiquitous starting materials in a single chemical step. Carbohydroxylations of …
Discovery, characterization, engineering, and applications of ene-reductases for industrial biocatalysis
HS Toogood, NS Scrutton - ACS catalysis, 2018 - ACS Publications
Recent studies of multiple enzyme families collectively called ene-reductases (ERs) have
highlighted potential industrial applications of these biocatalysts in the production of fine and …
highlighted potential industrial applications of these biocatalysts in the production of fine and …
Biocatalytic reduction reactions from a chemist's perspective
F Hollmann, DJ Opperman… - Angewandte Chemie …, 2021 - Wiley Online Library
Reductions play a key role in organic synthesis, producing chiral products with new
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …
[HTML][HTML] Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent 'ene'-reductases
MJ Black, KF Biegasiewicz, AJ Meichan… - Nature …, 2020 - nature.com
Abstract Flavin-dependent 'ene'-reductases (EREDs) are exquisite catalysts for effecting
stereoselective reductions. Although these reactions typically proceed through a hydride …
stereoselective reductions. Although these reactions typically proceed through a hydride …
Ene‐reductase: a multifaceted biocatalyst in organic synthesis
T Kumar Roy, R Sreedharan, P Ghosh… - … A European Journal, 2022 - Wiley Online Library
Biocatalysis integrate microbiologists, enzymologists, and organic chemists to access the
repertoire of pharmaceutical and agrochemicals with high chemoselectivity, regioselectivity …
repertoire of pharmaceutical and agrochemicals with high chemoselectivity, regioselectivity …
Cyclopentyl methyl ether (CPME): a versatile eco‐friendly solvent for applications in biotechnology and biorefineries
G de Gonzalo, AR Alcántara… - …, 2019 - Wiley Online Library
The quest for sustainable solvents is currently a matter of intense research and
development, as solvents significantly contribute heavily to the waste generated by chemical …
development, as solvents significantly contribute heavily to the waste generated by chemical …