[HTML][HTML] Deep learning in drug discovery: an integrative review and future challenges
H Askr, E Elgeldawi, H Aboul Ella… - Artificial Intelligence …, 2023 - Springer
Recently, using artificial intelligence (AI) in drug discovery has received much attention
since it significantly shortens the time and cost of developing new drugs. Deep learning (DL) …
since it significantly shortens the time and cost of developing new drugs. Deep learning (DL) …
[HTML][HTML] Omicron variant (B. 1.1. 529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?
M Dhawan, ARA Saied, S Mitra, FA Alhumaydhi… - Biomedicine & …, 2022 - Elsevier
Since the start of the COVID-19 pandemic, numerous variants of SARS-CoV-2 have been
reported worldwide. The advent of variants of concern (VOCs) raises severe concerns amid …
reported worldwide. The advent of variants of concern (VOCs) raises severe concerns amid …
SynergyFinder 3.0: an interactive analysis and consensus interpretation of multi-drug synergies across multiple samples
Abstract SynergyFinder (https://synergyfinder. fimm. fi) is a free web-application for
interactive analysis and visualization of multi-drug combination response data. Since its first …
interactive analysis and visualization of multi-drug combination response data. Since its first …
[HTML][HTML] SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination
Dear Editor, Since the first outbreak in late 2019, the RNA genome of SARS-CoV-2 has
been undergoing constant evolution. This is largely attributed to the viral polymerase that is …
been undergoing constant evolution. This is largely attributed to the viral polymerase that is …
[HTML][HTML] Lassa fever—the road ahead
RF Garry - Nature Reviews Microbiology, 2023 - nature.com
Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …
[HTML][HTML] Viral membrane fusion: a dance between proteins and lipids
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …
members of high concern for global human health. All enveloped viruses have a dedicated …
[HTML][HTML] In silico repurposed drugs against monkeypox virus
Monkeypox is an emerging epidemic of concern. The disease is caused by the monkeypox
virus and an increasing global incidence with a 2022 outbreak that has spread to Europe …
virus and an increasing global incidence with a 2022 outbreak that has spread to Europe …
[HTML][HTML] The combination of molnupiravir with nirmatrelvir or GC376 has a synergic role in the inhibition of SARS-CoV-2 replication in vitro
A Gidari, S Sabbatini, E Schiaroli, S Bastianelli… - Microorganisms, 2022 - mdpi.com
Introduction: The development of effective vaccines has partially mitigated the trend of the
SARS-CoV-2 pandemic; however, the need for orally administered antiviral drugs persists …
SARS-CoV-2 pandemic; however, the need for orally administered antiviral drugs persists …
Discovery of Amphiphilic Xanthohumol Derivatives as Membrane-Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus
W Cheng, T Xu, L Cui, Z Xue, J Liu… - Journal of Medicinal …, 2022 - ACS Publications
Infections caused by multidrug-resistant (MDR) bacteria are increasing worldwide, and with
limited clinically available antibiotics, it is urgent to develop new antimicrobials to combat …
limited clinically available antibiotics, it is urgent to develop new antimicrobials to combat …
[HTML][HTML] A dual graph neural network for drug–drug interactions prediction based on molecular structure and interactions
M Ma, X Lei - PLOS Computational Biology, 2023 - journals.plos.org
Expressive molecular representation plays critical roles in researching drug design, while
effective methods are beneficial to learning molecular representations and solving related …
effective methods are beneficial to learning molecular representations and solving related …