Myocardial fibrosis from the perspective of the extracellular matrix: mechanisms to clinical impact
Fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) and
constitutes a central pathophysiological process that underlies tissue dysfunction, across …
constitutes a central pathophysiological process that underlies tissue dysfunction, across …
The role of nonmyocardial cells in the development of diabetic cardiomyopathy and the protective effects of FGF21: a current understanding
T Zhang, D Jiang, X Zhang, L Chen, J Jiang… - Cell Communication and …, 2024 - Springer
Diabetic cardiomyopathy (DCM) represents a unique myocardial disease originating from
diabetic metabolic disturbances that is characterized by myocardial fibrosis and diastolic …
diabetic metabolic disturbances that is characterized by myocardial fibrosis and diastolic …
Dietary capsaicin attenuates cardiac injury after myocardial infarction in type 2 diabetic mice by inhibiting ferroptosis through activation of TRPV1 and Nrf2/HMOX1 …
C Yang, W Guo, R He, X Meng, J Fu, Y Lu - International …, 2024 - Elsevier
Background Type 2 diabetes mellitus (T2DM) is a major 21st-century epidemic. T2DM
elevates the risk of myocardial infarction and heart failure while also reducinges survival …
elevates the risk of myocardial infarction and heart failure while also reducinges survival …
Cardamonin protects against diabetic cardiomyopathy by activating macrophage NRF2 signaling through molecular interaction with KEAP1
Diabetic cardiomyopathy (DCM) contributes to a large proportion of heart failure incidents in
the diabetic population, but effective therapeutic approaches are rare. Cardamonin (CAD), a …
the diabetic population, but effective therapeutic approaches are rare. Cardamonin (CAD), a …
LincR-PPP2R5C regulates the PP2A signaling pathway in the macrophage-myofibroblast transition in a mouse model of epidural fibrosis
J Sun, M Shi, R Mei, Y Zhao, Y Huang, Z Song… - Molecular …, 2025 - Elsevier
Low back pain after spine surgery is a major complication due to excessive epidural fibrosis,
which compresses the lumbar nerve. Macrophage–myofibroblast transition (MMT) promoted …
which compresses the lumbar nerve. Macrophage–myofibroblast transition (MMT) promoted …