Membrane proteins play critical physiological roles in all organisms, from ion transport and
signal transduction to multidrug resistance. Elucidating their 3D structures is essential for …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

Acid-sensing ion channels (ASICs) are proton-gated members of the epithelial sodium
channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout …

Over the past decade, the vast amount of information generated through structural and
biophysical studies of GPCRs has provided unprecedented mechanistic insight into the …

The advent of amphiphilic copolymers enables integral membrane proteins to be solubilized
into stable 10–30 nm native nanodiscs to resolve their multisubunit structures, post …

While it is known that lipids play an essential role in regulating membrane protein structure
and function, it remains challenging to identify specific protein–lipid interactions. Here, we …

Styrene–maleic acid (SMA) copolymers are a promising alternative to detergents for the
solubilization of membrane proteins. Here we employ Escherichia coli membranes …

Amphipathic copolymers such as poly (styrene-maleic acid)(SMA) are promising tools for the
facile extraction of membrane proteins (MPs) into native nanodiscs. Here, we designed and …

Membrane proteins and lipids play roles in regulating biological functions of cells. However,
the analysis of interactions between membrane proteins and lipids in biological membranes …

Dopamine receptors (DRs) are class A G-Protein Coupled Receptors (GPCRs) prevalent in
the central nervous system (CNS). These receptors mediate physiological functions ranging …