[HTML][HTML] The role of organ-deposited IgG in the pathogenesis of multi-organ and tissue damage in systemic lupus erythematosus

W Qiu, T Yu, GM Deng - Frontiers in Immunology, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE), often known simply as lupus, is a severe chronic
autoimmune disease that is characterized by multi-organ and tissue damage and high levels …

Recent advances in understanding pathogenesis and therapeutic strategies of Systemic Lupus Erythematosus

S Luo, H Long, Q Lu - International Immunopharmacology, 2020 - Elsevier
Systemic lupus erythematosus (SLE) is a multi-system-involving autoimmune disorder
mainly affecting young and middle-aged women. Autoantibodies formation and immune …

NKG2D discriminates diverse ligands through selectively mechano‐regulated ligand conformational changes

J Fan, J Shi, Y Zhang, J Liu, C An, H Zhu, P Wu… - The EMBO …, 2022 - embopress.org
Stimulatory immune receptor NKG2D binds diverse ligands to elicit differential anti‐tumor
and anti‐virus immune responses. Two conflicting degeneracy recognition models based on …

[HTML][HTML] Mechanical activation of spike fosters SARS-CoV-2 viral infection

W Hu, Y Zhang, P Fei, T Zhang, D Yao, Y Gao, J Liu… - Cell Research, 2021 - nature.com
The outbreak of SARS-CoV-2 (SARS2) has caused a global COVID-19 pandemic. The spike
protein of SARS2 (SARS2-S) recognizes host receptors, including ACE2, to initiate viral …

[HTML][HTML] Treatment of allergic eosinophilic asthma through engineered IL-5-anchored chimeric antigen receptor T cells

S Chen, G Chen, F Xu, B Sun, X Chen, W Hu, F Li… - Cell Discovery, 2022 - nature.com
Severe eosinophilic asthma (SEA) is a therapy-resistant respiratory condition with poor
clinical control. Treatment efficacy and patient compliance of current therapies remain …

Ultra-stable biomembrane force probe for accurately determining slow dissociation kinetics of PD-1 blockade antibodies on single living cells

C An, W Hu, J Gao, BF Ju, P Obeidy, YC Zhao, X Tu… - Nano Letters, 2020 - ACS Publications
Immune checkpoint blockade with monoclonal antibodies (mAbs) that target programmed
cell death protein-1 (PD-1) has remarkably revolutionized cancer therapy. Their binding …

[HTML][HTML] Plasma membrane integrates biophysical and biochemical regulation to trigger immune receptor functions

T Zhang, W Hu, W Chen - Frontiers in Immunology, 2021 - frontiersin.org
Plasma membrane provides a biophysical and biochemical platform for immune cells to
trigger signaling cascades and immune responses against attacks from foreign pathogens …

[HTML][HTML] Insights into intercellular receptor-ligand binding kinetics in cell communication

C An, X Wang, F Song, J Hu, L Li - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Cell-cell communication is crucial for cells to sense, respond and adapt to environmental
cues and stimuli. The intercellular communication process, which involves multiple length …

[HTML][HTML] Impacts of FcγRIIB and FcγRIIIA gene polymorphisms on systemic lupus erythematous disease activity index

M Karimifar, K Akbari, R ArefNezhad, F Fathi… - BMC Research …, 2021 - Springer
Objective Systemic lupus erythematous (SLE) disease is a chronic autoimmune disease with
unknown etiology that can involve different organs. Polymorphisms in Fcγ receptors have …

B cell activation and autoantibody production in autoimmune diseases

W Sun, C Zhu, Y Li, X Wu, X Shi, W Liu - Best Practice & Research Clinical …, 2024 - Elsevier
B cells are central players in the immune system, responsible for producing antibodies and
modulating immune responses. This review explores the intricate relationship between …