Animal models of depression are certainly needed but the question in the title has been
raised owing to the controversies in the interpretation of the readout in a number of tests, to …

The chronic social defeat stress model has been instrumental in shaping our understanding
of neurobiology relevant to affect-related illnesses, including major depressive disorder …

Selective serotonin reuptake inhibitors (SSRIs) constitute a first-line antidepressant
intervention, though the precise cognitive and computational mechanisms that explain …

Major depression (MD) is a severe mental illness and creates a heavy social burden, and
the potential molecular mechanisms remain largely unknown. Lots of researches …

The ability of the N-methyl-d-aspartate receptor antagonist ketamine to induce a rapid and
sustained antidepressant effect has led to a surge in pre-clinical studies investigating …

The purpose of this study was to estimate the pharmacological effect of geniposide (GEN) on
depression, caused by chronic unpredictable mild stress (CUMS), and explore its potential …

Patchouli alcohol (PA), a tricyclic sesquiterpene, is the major chemical component of
patchouli oil. This study investigated the antidepressant-like effect and mechanism of PA in …

Simple Summary For laboratory mice, handling methods used for routine husbandry and
procedures can cause stress, particularly if tail handling methods are used. We first sought …

Blinding of treatment allocation in clinical trials in psychiatry is regarded as an ideal. The
potential impact of unblinding chimes with a general concern for psychological research: so …

Abstract RUTHERFORD, LG and Milton, AL Deconstructing and reconstructing behaviour
relevant to mental health disorders: The benefits of a psychological approach, with a focus …