[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy

M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Effects of mesenchymal stem cell-derived exosomes on autoimmune diseases

Z Shen, W Huang, J Liu, J Tian, S Wang… - Frontiers in …, 2021 - frontiersin.org
Recent years, the immunosuppressive properties of mesenchymal stem cells (MSCs) have
been demonstrated in preclinical studies and trials of inflammatory and autoimmune …

Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases

S Dabrowska, A Andrzejewska, M Janowski… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …

[HTML][HTML] Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis

S Cosenza, K Toupet, M Maumus, P Luz-Crawford… - Theranostics, 2018 - ncbi.nlm.nih.gov
Objectives: Mesenchymal stem cells (MSCs) release extracellular vesicles (EVs) that display
a therapeutic effect in inflammatory disease models. Although MSCs can prevent arthritis …

Insights into the secretome of mesenchymal stem cells and its potential applications

S Eleuteri, A Fierabracci - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can
be easily isolated and expanded in vitro. Despite being a powerful tool for clinical …

The immunomodulatory functions of mesenchymal stromal/stem cells mediated via paracrine activity

Y Zhou, Y Yamamoto, Z Xiao, T Ochiya - Journal of clinical medicine, 2019 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) exist in almost all tissues, possessing the potential
to differentiate into specialized cell types and exert immunomodulatory functions. Thus, they …

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives

S Regmi, S Pathak, JO Kim, CS Yong… - European journal of cell …, 2019 - Elsevier
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …

Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model

M Khatri, LA Richardson, T Meulia - Stem cell research & therapy, 2018 - Springer
Background Mesenchymal stem (stromal) cells (MSCs) mediate their immunoregulatory and
tissue repair functions by secreting paracrine factors, including extracellular vesicles (EVs) …

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European …

JPG Sluijter, SM Davidson, CM Boulanger… - Cardiovascular …, 2018 - academic.oup.com
Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting
considerable interest in the cardiovascular field as the wide range of their functions is …

Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy

S Kourembanas - Annual review of physiology, 2015 - annualreviews.org
Mesenchymal stem cells (MSCs), whose mechanism of action is predominantly paracrine,
are being widely tested for the treatment of a variety of human diseases. No one factor has …