[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy
M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
Effects of mesenchymal stem cell-derived exosomes on autoimmune diseases
Recent years, the immunosuppressive properties of mesenchymal stem cells (MSCs) have
been demonstrated in preclinical studies and trials of inflammatory and autoimmune …
been demonstrated in preclinical studies and trials of inflammatory and autoimmune …
Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases
S Dabrowska, A Andrzejewska, M Janowski… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …
[HTML][HTML] Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis
S Cosenza, K Toupet, M Maumus, P Luz-Crawford… - Theranostics, 2018 - ncbi.nlm.nih.gov
Objectives: Mesenchymal stem cells (MSCs) release extracellular vesicles (EVs) that display
a therapeutic effect in inflammatory disease models. Although MSCs can prevent arthritis …
a therapeutic effect in inflammatory disease models. Although MSCs can prevent arthritis …
Insights into the secretome of mesenchymal stem cells and its potential applications
S Eleuteri, A Fierabracci - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) have regenerative, immunoregulatory properties and can
be easily isolated and expanded in vitro. Despite being a powerful tool for clinical …
be easily isolated and expanded in vitro. Despite being a powerful tool for clinical …
The immunomodulatory functions of mesenchymal stromal/stem cells mediated via paracrine activity
Y Zhou, Y Yamamoto, Z Xiao, T Ochiya - Journal of clinical medicine, 2019 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) exist in almost all tissues, possessing the potential
to differentiate into specialized cell types and exert immunomodulatory functions. Thus, they …
to differentiate into specialized cell types and exert immunomodulatory functions. Thus, they …
Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …
Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model
M Khatri, LA Richardson, T Meulia - Stem cell research & therapy, 2018 - Springer
Background Mesenchymal stem (stromal) cells (MSCs) mediate their immunoregulatory and
tissue repair functions by secreting paracrine factors, including extracellular vesicles (EVs) …
tissue repair functions by secreting paracrine factors, including extracellular vesicles (EVs) …
Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European …
Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting
considerable interest in the cardiovascular field as the wide range of their functions is …
considerable interest in the cardiovascular field as the wide range of their functions is …
Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy
S Kourembanas - Annual review of physiology, 2015 - annualreviews.org
Mesenchymal stem cells (MSCs), whose mechanism of action is predominantly paracrine,
are being widely tested for the treatment of a variety of human diseases. No one factor has …
are being widely tested for the treatment of a variety of human diseases. No one factor has …