Synaptic targets: Chronic alcohol actions

M Roberto, FP Varodayan - Neuropharmacology, 2017 - Elsevier
Alcohol acts on numerous cellular and molecular targets to regulate neuronal
communication within the brain. Chronic alcohol exposure and acute withdrawal generate …

Synaptic effects induced by alcohol

DM Lovinger, M Roberto - 2023 - Springer
Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in
synaptic function are prominent among these effects. Acute exposure to EtOH activates or …

Does moderate drinking harm the fetal brain? Insights from animal models

CF Valenzuela, RA Morton, MR Diaz, L Topper - Trends in neurosciences, 2012 - cell.com
Although public health campaigns advise pregnant women to abstain from ethanol, drinking
during pregnancy is pervasive. Here, we highlight recent studies that have clearly …

Ethanol modulation of GABAergic transmission: the view from the slice

JL Weiner, CF Valenzuela - Pharmacology & therapeutics, 2006 - Elsevier
For almost three decades now, the GABAergic synapse has been the focus of intense study
for its putative role in mediating many of the behavioral consequences associated with acute …

Alcohol as an early life stressor: Epigenetics, metabolic, neuroendocrine and neurobehavioral implications

S Ciafrè, G Ferraguti, A Greco, A Polimeni… - Neuroscience & …, 2020 - Elsevier
Ethanol exposure during gestation is an early life stressor that profoundly dysregulates
structure and functions of the embryonal nervous system, altering the cognitive and …

Neural mechanisms of pain and alcohol dependence

AV Apkarian, V Neugebauer, G Koob… - Pharmacology …, 2013 - Elsevier
An association between chronic pain conditions and alcohol dependence has been
revealed in numerous studies with episodes of alcohol abuse antedating chronic pain in …

Effects of pre-natal alcohol exposure on hippocampal synaptic plasticity: Sex, age and methodological considerations

CJ Fontaine, AR Patten, HM Sickmann, JL Helfer… - Neuroscience & …, 2016 - Elsevier
The consumption of alcohol during gestation is detrimental to the developing central
nervous system (CNS). The severity of structural and functional brain alterations associated …

Effect of alcohol on hippocampal-dependent plasticity and behavior: role of glutamatergic synaptic transmission

RG Mira, M Lira, C Tapia-Rojas… - Frontiers in behavioral …, 2020 - frontiersin.org
Problematic alcohol drinking and alcohol dependence are an increasing health problem
worldwide. Alcohol abuse is responsible for approximately 5% of the total deaths in the …

Acute effects of ethanol on glutamate receptors

T Möykkynen, ER Korpi - Basic & clinical pharmacology & …, 2012 - Wiley Online Library
Several studies have revealed that acute ethanol inhibits the function of glutamate receptors.
Glutamate receptor‐mediated synaptic plasticity, such as N‐methyl‐d‐aspartate‐dependent …

[HTML][HTML] Focus on: neurotransmitter systems

CF Valenzuela, MP Puglia, S Zucca - Alcohol Research & Health, 2011 - ncbi.nlm.nih.gov
Neurotransmitter systems have been long recognized as important targets of the
developmental actions of alcohol (ie, ethanol). Short-and long-term effects of ethanol on …