The role of von Willebrand factor in vascular inflammation: from pathogenesis to targeted therapy

F Gragnano, S Sperlongano, E Golia… - Mediators of …, 2017 - Wiley Online Library
Beyond its role in hemostasis, von Willebrand factor (VWF) is an emerging mediator of
vascular inflammation. Recent studies highlight the involvement of VWF and its regulator …

Shear stress-induced activation of von Willebrand factor and cardiovascular pathology

S Okhota, I Melnikov, Y Avtaeva, S Kozlov… - International Journal of …, 2020 - mdpi.com
The von Willebrand factor (vWF) is a plasma protein that mediates platelet adhesion and
leukocyte recruitment to vascular injury sites and carries coagulation factor VIII, a building …

Endothelial cell markers from clinician's perspective

J Rakocevic, D Orlic, O Mitrovic-Ajtic… - … and molecular pathology, 2017 - Elsevier
Endothelial cell markers are membrane-bound or cytoplasmic molecules expressed by
endothelial cells, which help their easier identification and discrimination from other cell …

The role of selenium in atherosclerosis development, progression, prevention and treatment

SA Dabravolski, VN Sukhorukov, AA Melnichenko… - Biomedicines, 2023 - mdpi.com
Selenium is an essential trace element that is essential for various metabolic processes,
protection from oxidative stress and proper functioning of the cardiovascular system. Se …

Regulation of VWF expression, and secretion in health and disease

Y Xiang, J Hwa - Current opinion in hematology, 2016 - journals.lww.com
VWF biosynthesis, maturation, and secretion is a complex process, which mandates tight
regulation. Significant progress has been made in our understandings of VWF expression …

Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue

SF Riswari, RN Tunjungputri, V Kullaya… - PLoS …, 2019 - journals.plos.org
Thrombocytopenia and platelet dysfunction are commonly observed in patients with dengue
virus (DENV) infection and may contribute to complications such as bleeding and plasma …

Update on ADAMTS13 and VWF in cardiovascular and hematological disorders

O Akyol, S Akyol, CH Chen - Clinica chimica acta, 2016 - Elsevier
Endothelial cells (EC) respond to injury by releasing numerous factors, including von
Willebrand factor (VWF). High circulating levels of unusually large VWF multimers (UL …

Fibrinogen to HDL-Cholesterol ratio as a predictor of mortality risk in patients with acute myocardial infarction

C Jia, W Wu, H Lu, J Liu, S Chen, G Liang… - Lipids in Health and …, 2024 - Springer
Background Acute myocardial infarction (AMI) is characterized by inflammation, oxidative
stress, and atherosclerosis, contributing to increased mortality risk. High-density lipoprotein …

Von Willebrand factor (vWF) in patients with heart failure with preserved ejection fraction (HFpEF): A retrospective observational study

M Abudoukelimu, B Ba, YK Guo, J Xu - Medicine, 2022 - journals.lww.com
Heart failure with preserved ejection fraction (HFpEF) is associated with endothelial damage
and inflammation. In addition, von Willebrand factor (vWF) has been discovered as a …

Von Willebrand factor and cardiovascular disease: from a biochemical marker to an attractive therapeutic target

F Gragnano, E Golia, F Natale… - Current Vascular …, 2017 - ingentaconnect.com
Background: Despite recent advances, there is still an unmet need in antithrombotic therapy.
New drugs have to overcome old targets, looking for new complementary strategies to …