Infection as a stroke risk factor and determinant of outcome after stroke

MSV Elkind, AK Boehme, CJ Smith, A Meisel… - Stroke, 2020 - Am Heart Assoc
Understanding the relationship between infection and stroke has taken on new urgency in
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …

Cytokines as therapeutic targets for cardio-and cerebrovascular diseases

L Liberale, S Ministrini, F Carbone, GG Camici… - Basic Research in …, 2021 - Springer
Despite major advances in prevention and treatment, cardiac and cerebral atherothrombotic
complications still account for substantial morbidity and mortality worldwide. In this context …

Sympathetic-Mediated Intestinal Cell Death Contributes to Gut Barrier Impairment After Stroke

K Prame Kumar, LD McKay, H Nguyen, J Kaur… - Translational Stroke …, 2023 - Springer
Tissue injury induced by stroke is traditionally thought to be localised to the brain. However,
there is an accumulating body of evidence to demonstrate that stroke promotes …

The efficacy and safety of interleukin-1 receptor antagonist in stroke patients: A systematic review

S Kazmi, H Salehi-Pourmehr, S Sadigh-Eteghad… - Journal of Clinical …, 2024 - Elsevier
Stroke is the leading cause of disability worldwide, yet there is currently no effective
treatment available to mitigate its negative consequences. Pro-inflammatory cytokines, such …

Post‐stroke immunosuppression: Exploring potential implications beyond infections

D Brea - European Journal of Neuroscience, 2023 - Wiley Online Library
Stroke is a leading cause of mortality and disability. It occurs when cerebral blood flow is
disrupted via vascular occlusion or rupture, causing tissue damage. Research has …

Treatment with IgM‐enriched intravenous immunoglobulins enhances clearance of stroke‐associated bacterial lung infection

L McCulloch, AJ Harris, A Malbon, MJD Daniels… - …, 2022 - Wiley Online Library
Post‐stroke infection is a common complication of stroke that is associated with poor
outcome. We previously reported that stroke induces an ablation of multiple sub‐populations …

A hyperacute immune map of ischaemic stroke patients reveals alterations to circulating innate and adaptive cells

S Krishnan, C O'Boyle, CJ Smith… - Clinical & …, 2021 - academic.oup.com
Systemic immune changes following ischaemic stroke are associated with increased
susceptibility to infection and poor patient outcome due to their role in exacerbating the …

Flow cytometry-based peripheral blood analysis as an easily friendly tool for prognostic monitoring of acute ischemic stroke: a multicenter study

K Lu, W Ni, J Yue, Y Cheng, J Du, Y Li, X Tong… - Frontiers in …, 2024 - frontiersin.org
Background and objective Acute ischemic stroke (AIS) is a leading cause of mortality, severe
neurological and long-term disability world-wide. Blood-based indicators may provide …

Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion

AA Tuz, S Ghosh, L Karsch, D Ttoouli, SP Sata… - Nature Cardiovascular …, 2024 - nature.com
Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in
cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal …

[HTML][HTML] The role of β2 adrenergic receptor on infection development after ischaemic stroke

R Shim, JL Wilson, SE Phillips, GW Lambert… - Brain, Behavior, & …, 2021 - Elsevier
Mechanisms underlying post-stroke immune impairments and subsequent development of
fatal lung infection have been suggested to involve multiple pathways, including …