Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional or
superfluous mitochondria, thus fine-tuning mitochondrial number and preserving energy …

Disruption of autophagy plays an import role in neurodegenerative disorders, where
deficient elimination of abnormal and toxic protein aggregates promotes cellular stress …

Increasing interest has recently focused on determining whether several natural
compounds, collectively referred to as nutraceuticals, may exert neuroprotective actions in …

Converging evidence from genetic, pathological and experimental studies have increasingly
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …

Iron is an essential micronutrient that is problematic for biological systems since it is toxic as
it generates free radicals by interconverting between ferrous (Fe 2+) and ferric (Fe 3+) forms …

Cerebral ischemia-reperfusion (IR) is a complex pathological process. Although autophagy
can be evoked by ischemia, its involvement in the reperfusion phase after ischemia and its …

Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a
variety of processes such as development or the prevention of oncogenic transformation …

Inflammation is likely a key contributor to the pathogenesis of Parkinson's disease (PD), a
progressively debilitating neurodegenerative disease that is accompanied by a pathological …

Oxidative stress including DNA damage, increased lipid and protein oxidation, are important
features of aging and neurodegeneration suggesting that endogenous antioxidant protective …

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains | Movement Disorders
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