During mitosis, the interaction of kinetochores (KTs) with microtubules (MTs) drives
chromosome congression to the spindle equator and supports the segregation of sister …

The fruit fly Drosophila melanogaster serves as a powerful model organism for advancing
our understanding of biological processes, not just by studying its similarities with other …

MyD88 is a typical street protein of the TLRs signaling pathway and is a central player in
innate immune signaling, which can regulate the NF-κB signaling pathway and promote …

To maintain genome stability, chromosomes must be equally distributed among daughter
cells at the end of mitosis. The accuracy of chromosome segregation requires sister …

Centromeres are essential chromosomal landmarks that dictate the point of attachment
between chromosomes and spindle microtubules during cell division. The stable …

Abstract Cyclin‑dependent kinase 4 (CDK4) is a critical molecule that regulates key aspects
of cell proliferation through phosphorylation of the retinoblastoma (Rb) family of proteins. In …

This study explored the function and mechanism of RAD50 interactor 1 (RINT1), Zeste white
10 (ZW10) or nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) in cell growth of …

In many metazoans, centromeres are embedded in large blocks of highly repetitive (peri-)
centromeric heterochromatin from which non-coding RNAs emanate that have been …

CENP-A is a centromere-specific histone H3 variant that is required to ensure kinetochore
assembly for proper chromosome segregation and its function is highly conserved among …

The centromere is an essential locus for chromosome segregation. It serves as a platform for
kinetochore assembly and subsequent spindle microtubule attachment during cell division …