The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Metastasis is a distinct stage of cancer progression that requires the development of
angiogenic blood vessels serving as conduits for tumor cell dissemination. An accumulated …

Inflammation in the tumor microenvironment is now recognized as one of the hallmarks of
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid …

Cancer metastasis is a malignant process by which tumor cells migrate from their primary
site of origin to other organs. It is the main cause of poor prognosis in cancer patients …

Tumor-associated macrophages (TAMs) play an essential role in metastasis. However, what
enables TAMs to have a superior capacity to establish pre-metastatic microenvironment in …

Cytochrome P450 (CYP) 4Z1, a novel CYP4 family member, is over-expressed in human
mammary carcinoma and associated with high-grade tumors and poor prognosis. However …

hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic acid that exhibits a
myriad of biological effects in the vascular system. This review discusses the current …

A major problem associated with cancer treatment is resistance-prone chemotherapeutic
drugs. An increasing number of studies have documented that the occurrence of resistance …

Background Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-
2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 …

Cytochrome P450-dependent ω-hydroxylation is a prototypic metabolic reaction of CYP4
family members that is important for the elimination and bioactivation of not only therapeutic …