Stress and cancer: mechanisms, significance and future directions

A Eckerling, I Ricon-Becker, L Sorski… - Nature Reviews …, 2021 - nature.com
The notion that stress and cancer are interlinked has dominated lay discourse for decades.
More recent animal studies indicate that stress can substantially facilitate cancer …

Antidepressants for the treatment of depression in people with cancer

G Ostuzzi, F Matcham, S Dauchy… - Cochrane Database …, 2018 - cochranelibrary.com
Background Major depression and other depressive conditions are common in people with
cancer. These conditions are not easily detectable in clinical practice, due to the overlap …

Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils

M Perego, VA Tyurin, YY Tyurina, J Yellets… - Science translational …, 2020 - science.org
Tumor recurrence years after seemingly successful treatment of primary tumors is one of the
major causes of mortality in patients with cancer. Reactivation of dormant tumor cells is …

Understanding the role of dopamine in cancer: past, present and future

CE Grant, AL Flis, BM Ryan - Carcinogenesis, 2022 - academic.oup.com
Abstract Dopamine (DA, 3-hydroxytyramine) is a member of the catecholamine family and is
classically characterized according to its role in the central nervous system as a …

Suppression of EGFR/PKC-δ/NF-κB signaling associated with imipramine-inhibited progression of non-small cell lung cancer

PF Yueh, YH Lee, IT Chiang, WT Chen, KL Lan… - Frontiers in …, 2021 - frontiersin.org
Background Anti-depressants have been reported to own anti-tumor potential types of
cancers; however, the role of imipramine in non-small cell lung cancer (NSCLC) has not …

Understanding and modeling nerve–cancer interactions

TT Le, MJ Oudin - Disease Models & Mechanisms, 2023 - journals.biologists.com
The peripheral nervous system plays an important role in cancer progression. Studies in
multiple cancer types have shown that higher intratumoral nerve density is associated with …

Antidepressant use and mortality among patients with hepatocellular carcinoma

KL Huang, YL Chen, R Stewart… - JAMA Network Open, 2023 - jamanetwork.com
Importance Liver cancer, primarily hepatocellular carcinoma (HCC), is the third leading
cause of cancer deaths worldwide. Although some studies have proposed that …

Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy

PED Chung, DMA Gendoo… - Nature …, 2020 - nature.com
Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor
suppressors RB1 or DICER1. Presence of leptomeningeal metastases is indicative of poor …

Monotherapy efficacy of blood–brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma

J Merisaari, OV Denisova, M Doroszko… - Brain …, 2020 - academic.oup.com
Glioblastoma is a fatal disease in which most targeted therapies have clinically failed.
However, pharmacological reactivation of tumour suppressors has not been thoroughly …

HTR1A Inhibits the Progression of Triple‐Negative Breast Cancer via TGF‐β Canonical and Noncanonical Pathways

Q Liu, H Sun, Y Liu, X Li, B Xu, L Li, W Jin - Advanced Science, 2022 - Wiley Online Library
Triple‐negative breast cancer is the most aggressive subtype of breast cancer and the
incidence of depression in breast cancer patients is high, which leading to worse survival …