Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain.
However, it is also produced in other sites; notably by pancreatic β cells and immune cells …

Type 1 diabetes is an autoimmune disease caused by the immune‐mediated destruction of
insulin‐producing pancreatic β cells. In recent years, the incidence of type 1 diabetes …

Type 1 Diabetes (T1D), also called juvenile diabetes because of its classically early onset, is
considered an autoimmune disease targeting the insulin-producing β cells in the pancreatic …

Diabetes occurs when pancreatic β‐cell death exceeds β‐cell growth, which leads to loss of
β‐cell mass. An effective therapy must have two actions: promotion of β‐cell replication and …

Abstract Type 1 diabetes (T1D) results from an aberrant immunological response against the
insulin-producing beta cells in the islets of the pancreas. The ideal therapy would restore …

Insulin-dependent or type 1 diabetes (T1D) is a paradigm for prevention of autoimmune
disease: Pancreatic β-cell autoantigens are defined, at-risk individuals can be identified …

Type 1 diabetes is an organ-specific autoimmune disease caused by chronic inflammation
(insulitis), which damages the insulin producing β-cells of the pancreatic Islets of …

Latent autoimmune diabetes in adults (LADA) is a type of diabetes characterized by slow
autoimmune damage of pancreatic β cells without insulin treatment in the early clinical …

Antigen-specific interventions are desirable approaches in Type 1 Diabetes (T1D) as they
can alter islet-specific autoimmunity without systemic side effects. Glutamic acid …