Applications and limitations of dendrimers in biomedicine

AA Chis, C Dobrea, C Morgovan, AM Arseniu, LL Rus… - Molecules, 2020 - mdpi.com
Biomedicine represents one of the main study areas for dendrimers, which have proven to
be valuable both in diagnostics and therapy, due to their capacity for improving solubility …

Polymer‐based mRNA delivery strategies for advanced therapies

W Yang, L Mixich, E Boonstra… - Advanced Healthcare …, 2023 - Wiley Online Library
Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety
of diseases. In 2020, two FDA approvals of mRNA‐based vaccines have elevated mRNA …

Dendrimers as nanocarriers for nucleic acid and drug delivery in cancer therapy

L Palmerston Mendes, J Pan, VP Torchilin - Molecules, 2017 - mdpi.com
Dendrimers are highly branched polymers with easily modifiable surfaces. This makes them
promising structures for functionalization and also for conjugation with drugs and DNA/RNA …

Dendrimers as pharmaceutical excipients: synthesis, properties, toxicity and biomedical applications

A Santos, F Veiga, A Figueiras - Materials, 2019 - mdpi.com
The European Medicines Agency (EMA) and the Current Good Manufacturing Practices
(cGMP) in the United States of America, define excipient as the constituents of the …

[HTML][HTML] Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential

H Kheraldine, O Rachid, AM Habib… - Advanced drug delivery …, 2021 - Elsevier
Drug delivery systems or vectors are usually needed to improve the bioavailability and
effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an …

Poly (propylene imine) dendrimer as an emerging polymeric nanocarrier for anticancer drug and gene delivery

V Singh, A Sahebkar, P Kesharwani - European Polymer Journal, 2021 - Elsevier
Dendrimers are well-defined globular macromolecules with multiple polymeric branching
that are amenable to undergo structural modifications. This property makes dendrimers …

Dendrimer as nanocarrier for drug delivery

P Kesharwani, K Jain, NK Jain - Progress in Polymer Science, 2014 - Elsevier
Dendrimers are novel three dimensional, hyperbranched globular nanopolymeric
architectures. Attractive features like nanoscopic size, narrow polydispersity index, excellent …

Oral delivery of anticancer drugs: challenges and opportunities

K Thanki, RP Gangwal, AT Sangamwar… - Journal of controlled …, 2013 - Elsevier
The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …

Dendrimer toxicity: Let's meet the challenge

K Jain, P Kesharwani, U Gupta, NK Jain - International journal of …, 2010 - Elsevier
Dendrimers are well-defined, versatile polymeric architecture with properties resembling
biomolecules. Dendritic polymers emerged as outstanding carrier in modern medicine …

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

AR Menjoge, RM Kannan, DA Tomalia - Drug discovery today, 2010 - Elsevier
Dendrimers are members of a versatile, fourth new class of polymer architecture (ie dendritic
polymers after traditional linear, crosslinked and branched types)[1]. Typically, dendrimers …