The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics
S Al Bitar, H Gali-Muhtasib - Cancers, 2019 - mdpi.com
p21 cip1/waf1 mediates various biological activities by sensing and responding to multiple
stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor …
stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor …
Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology
I Dutto, M Tillhon, O Cazzalini, LA Stivala… - Archives of toxicology, 2015 - Springer
The cell cycle inhibitor p21 CDKN1A is a protein playing multiple roles not only in the DNA
damage response, but also in many cellular processes during unperturbed cell growth. The …
damage response, but also in many cellular processes during unperturbed cell growth. The …
Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy
Tumor-associated macrophages (TAMs) are abundant in pancreatic ductal
adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the …
adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the …
Disease tolerance as an inherent component of immunity
Pathogenic organisms exert a negative impact on host health, revealed by the clinical signs
of infectious diseases. Immunity limits the severity of infectious diseases through resistance …
of infectious diseases. Immunity limits the severity of infectious diseases through resistance …
Inflammation and p53: a tale of two stresses
Numerous observations indicate a strong link between chronic inflammation and cancer.
This link is supported by substantial experimental evidence indicating mutual negative …
This link is supported by substantial experimental evidence indicating mutual negative …
p53 and the carcinogenicity of chronic inflammation
AV Gudkov, EA Komarova - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
Chronic inflammation is a major cancer predisposition factor. Constitutive activation of the
inflammation-driving NF-κB pathway commonly observed in cancer or developed in normal …
inflammation-driving NF-κB pathway commonly observed in cancer or developed in normal …
p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β
G Rackov, E Hernández-Jiménez… - The Journal of …, 2016 - Am Soc Clin Investig
M1 and M2 macrophage phenotypes, which mediate proinflammatory and antiinflammatory
functions, respectively, represent the extremes of immunoregulatory plasticity in the …
functions, respectively, represent the extremes of immunoregulatory plasticity in the …
Cyclin-dependent kinases as coregulators of inflammatory gene expression
ML Schmitz, M Kracht - Trends in pharmacological sciences, 2016 - cell.com
Cyclin-dependent kinases (CDKs) exert a variety of functions through regulation of the cell
cycle and gene expression, thus implicating them in diverse biological processes. Recent …
cycle and gene expression, thus implicating them in diverse biological processes. Recent …
Immunomodulatory roles of cell cycle regulators
P Laphanuwat, S Jirawatnotai - Frontiers in cell and developmental …, 2019 - frontiersin.org
Core cell cycle regulators, including cyclin-dependent kinases (CDKs), cyclins, and cyclin-
dependent kinase inhibitors (CKIs), are known for their well-characterized roles in cell …
dependent kinase inhibitors (CKIs), are known for their well-characterized roles in cell …
p16INK4a deficiency promotes IL-4–induced polarization and inhibits proinflammatory signaling in macrophages
The CDKN2A locus, which contains the tumor suppressor gene p16INK4a, is associated
with an increased risk of age-related inflammatory diseases, such as cardiovascular disease …
with an increased risk of age-related inflammatory diseases, such as cardiovascular disease …