Management of paediatric extracranial germ-cell tumours carries a unique set of challenges.
Germ-cell tumours are a heterogeneous group of neoplasms that present across a wide age …

During the past 35 years, survival rates for children with extracranial malignant germ cell
tumors (GCTs) have increased significantly. Success has been achieved primarily through …

Purpose To risk stratify malignant extracranial pediatric germ cell tumors (GCTs). Patients
and Methods Data from seven GCT trials conducted by the Children's Oncology Group …

Background The male excess in childhood cancer incidence is well‐established; however,
the underlying biologic mechanisms remain unknown. Examining the association between …

Most children with tumors will require one or more surgical interventions as part of the care
and treatment, including making a diagnosis, obtaining adequate venous access …

Childhood cancer five-year survival now exceeds 70–80%. Childhood exposure to radiation
is a known thyroid carcinogen; however, data are limited for the evaluation of radiation dose …

BACKGROUND: Malignant germ cell tumors (GCTs) are a rare and a heterogeneous group
of pediatric cancers. The incidence rate has increased in some populations or subgroups …

BACKGROUND Males with Klinefelter syndrome (KS)(47, XXY) may be more likely to
develop germ cell tumors (GCTs), particularly mediastinal GCTs. To date, there are no …

Background Pediatric and young adult central nervous system (CNS) germinomas have
favorable cure rates. However, long-term follow-up data are limited because of the rarity of …

Germ cell tumors (GCTs) are rare in childhood, representing only 3.5% of childhood
cancers, but a common malignancy in adolescents and young adults (AYAs), accounting for …