p53 family and cellular stress responses in cancer
J Pflaum, S Schlosser, M Müller - Frontiers in oncology, 2014 - frontiersin.org
p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …
p63 and p73, the ancestors of p53
V Dötsch, F Bernassola… - Cold Spring …, 2010 - cshperspectives.cshlp.org
p73 and p63 are two homologs of the tumor suppressive transcription factor p53. Given the
high degree of structural similarity shared by the p53 family members, p73 and p63 can bind …
high degree of structural similarity shared by the p53 family members, p73 and p63 can bind …
Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
S Kato, SY Han, W Liu, K Otsuka… - Proceedings of the …, 2003 - National Acad Sciences
Inactivation of the tumor suppressor p53 by missense mutations is the most frequent genetic
alteration in human cancers. The common missense mutations in the TP53 gene disrupt the …
alteration in human cancers. The common missense mutations in the TP53 gene disrupt the …
Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome
EEC syndrome is an autosomal dominant disorder characterized by ectrodactyly,
ectodermal dysplasia, and facial clefts. We have mapped the genetic defect in several EEC …
ectodermal dysplasia, and facial clefts. We have mapped the genetic defect in several EEC …
p63 regulates an adhesion programme and cell survival in epithelial cells
DK Carroll, JS Carroll, CO Leong, F Cheng… - Nature cell …, 2006 - nature.com
Abstract p63 is critical for epithelial development yet little is known about the transcriptional
programmes it regulates. By characterising transcriptional changes and cellular effects …
programmes it regulates. By characterising transcriptional changes and cellular effects …
DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
Several newly identified tumor suppressor genes including ATM, NBS1, BRCA1 and BRCA2
are involved in DNA double-strand break repair (DSBR) and DNA damage-induced …
are involved in DNA double-strand break repair (DSBR) and DNA damage-induced …
P63 and P73: P53 mimics, menaces and more
A Yang, F McKeon - Nature reviews Molecular cell biology, 2000 - nature.com
Inactivation of the tumour suppressor p53 is the most common defect in cancer cells. The
discovery of its two close relatives, p63 and p73, was therefore both provocative and …
discovery of its two close relatives, p63 and p73, was therefore both provocative and …
Hay–Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63
Hay–Wells syndrome, also known as ankyloblepharon–ectodermal dysplasia-clefting (AEC)
syndrome (OMIM 106260), is a rare autosomal dominant disorder characterized by …
syndrome (OMIM 106260), is a rare autosomal dominant disorder characterized by …
The common and distinct target genes of the p53 family transcription factors
K Harms, S Nozell, X Chen - Cellular and Molecular Life Sciences CMLS, 2004 - Springer
Abstract p53 is the most commonly mutated gene in human cancer. After activation by
cellular stresses such as DNA damage or oncogene activation, p53, a sequence-specific …
cellular stresses such as DNA damage or oncogene activation, p53, a sequence-specific …
p63α and ΔNp63α can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes
M Dohn, S Zhang, X Chen - Oncogene, 2001 - nature.com
The p53 tumor suppressor protein plays a critical role in the regulation of the cell cycle and
apoptosis. The importance of p53's functions is underscored by the high incidence of p53 …
apoptosis. The importance of p53's functions is underscored by the high incidence of p53 …