Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

MR Chaudhary, S Chaudhary, Y Sharma, TA Singh… - Biogerontology, 2023 - Springer
Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

Recent applications of vinyl sulfone motif in drug design and discovery

R Ahmadi, S Emami - European Journal of Medicinal Chemistry, 2022 - Elsevier
Vinyl sulfone with electrophilic character is not only a versatile building block for various
organic transformations but also is a key structural unit in a large number of biologically …

Diabetic retinopathy: Involved cells, biomarkers, and treatments

J Ren, S Zhang, Y Pan, M Jin, J Li, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR), a leading cause of vision loss and blindness worldwide, is
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …

[HTML][HTML] The cells involved in the pathological process of diabetic retinopathy

S Yang, J Zhang, L Chen - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Diabetic retinopathy (DR) is an expanding global health problem, the exact mechanism of
which has not yet been clarified clearly, new insights into retinal physiology indicate that …

A polysaccharide from Lycium barbarum L.: structure and protective effects against oxidative stress and high-glucose-induced apoptosis in ARPE-19 cells

J Liu, Y Li, Q Pu, H Qiu, D Di, Y Cao - International Journal of Biological …, 2022 - Elsevier
Lycium barbarum polysaccharides (LBPs) are beneficial for vision; however, relevant
research has mainly focused on entire crude polysaccharides, with the basis and exact …

[HTML][HTML] Inhibiting microRNA-144 potentiates Nrf2-dependent antioxidant signaling in RPE and protects against oxidative stress-induced outer retinal degeneration

RN Jadeja, MA Jones, AA Abdelrahman, FL Powell… - Redox biology, 2020 - Elsevier
The retinal pigment epithelium (RPE) is consistently exposed to high levels of pro-oxidant
and inflammatory stimuli. As such, under normal conditions the antioxidant machinery in the …

Multifunctional supramolecular filament hydrogel boosts anti‐inflammatory efficacy in vitro and in vivo

J Deng, D Lin, X Ding, Y Wang, YH Hu… - Advanced Functional …, 2022 - Wiley Online Library
Peptide‐drug conjugates (PDCs) are an important class of therapeutic agents that combine
one or more active molecules with a short peptide via a biodegradable spacer to generate …

Melatonin as a potential regulator of oxidative stress, and neuroinflammation: mechanisms and implications for the management of brain injury-induced …

M Ikram, HY Park, T Ali, MO Kim - Journal of Inflammation …, 2021 - Taylor & Francis
This review covers the preclinical and clinical literature supporting the role of melatonin in
the management of brain injury-induced oxidative stress, neuroinflammation, and …

Nrf2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): Novel …

EJ Calabrese, WJ Kozumbo, R Kapoor… - Radiotherapy and …, 2021 - Elsevier
Novel mechanistic insights are discussed herein that link a single, nontoxic, low-dose
radiotherapy (LDRT) treatment (0.5–1.0 Gy) to (1) beneficial subcellular effects mediated by …

The Essential Oils and Eucalyptol From Artemisia vulgaris L. Prevent Acetaminophen-Induced Liver Injury by Activating Nrf2–Keap1 and Enhancing APAP Clearance …

Z Jiang, X Guo, K Zhang, G Sekaran, B Cao… - Frontiers in …, 2019 - frontiersin.org
Artemisia has long been used in traditional medicine and as a food source for different
functions in eastern Asia. Artemisia vulgaris L.(AV) is a species of the genus Artemisia …