Over the past decade, comprehensive sequencing efforts have revealed the genomic
landscapes of common forms of human cancer. For most cancer types, this landscape …

Since the completion of the first human genome sequence and the advent of next generation
sequencing technologies, remarkable progress has been made in understanding the …

Sequencing has identified millions of somatic mutations in human cancers, but
distinguishing cancer driver genes remains a major challenge. Numerous methods have …

Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic
instability results from mutations in DNA repair genes and drives cancer development, as …

The division of medulloblastoma into different subgroups by microarray expression profiling
has dramatically changed our perspective of this malignant childhood brain tumour. Now …

With rare exceptions, spontaneous tumors originate from a single cell. Yet, at the time of
clinical diagnosis, the majority of human tumors display startling heterogeneity in many …

Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other
genetic mutations to the disease is largely unknown. Here, we describe the first completely …

More than 2% of the adult US population harbors a pancreatic cyst. These often pose a
difficult management problem because conventional criteria cannot always distinguish cysts …

The revolution in cancer research can be summed up in a single sentence: cancer is, in
essence, a genetic disease. In the last decade, many important genes responsible for the …

The systematic characterization of somatic mutations in cancer genomes is essential for
understanding the disease and for developing targeted therapeutics. Here we report the …