Recent studies have uncovered myriad viral sequences that are integrated
or'endogenized'in the genomes of various eukaryotes. Surprisingly, it appears that not just …

Retroviral replication involves the formation of a DNA provirus integrated into the host
genome. Through this process, retroviruses can colonize the germ line to form endogenous …

Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections
in the evolution of primates and account for about 8% of the human genome. They were …

Highlights•Endogenous viral elements (EVEs) account for a substantial fraction (∼ 10%) of
mammalian genomes.•EVEs represent an abundant source of coding and noncoding …

Long disregarded as junk DNA or genomic dark matter, endogenous retroviruses (ERVs)
have turned out to represent important components of the antiviral immune response. These …

Retroviruses integrate their reverse transcribed genomes into host cell chromosomes as an
obligate step in virus replication. The nuclear envelope separates the chromosomes from …

Animal genomes contain endogenous viral sequences, such as endogenous retroviruses
and retrotransposons. Recently, we and others discovered that nonretroviral viruses also …

Restriction factors (RFs) form important components of host defenses to retroviral infection.
The Fv1, Trim5α, and TrimCyp RFs contain N-terminal dimerization and C-terminal …

Saccharomyces cerevisiae and Saccharomyces paradoxus lack the conserved RNA
interference pathway and utilize a novel form of copy number control (CNC) to inhibit Ty1 …

The antiviral factor CPSF6-358 restricts human immunodeficiency virus type 1 (HIV-1)
infection through an interaction with capsid (CA), preventing virus nuclear entry and …