Reciprocality between estrogen biology and calcium signaling in the cardiovascular system

QK Tran - Frontiers in Endocrinology, 2020 - frontiersin.org
17β-Estradiol (E2) is the main estrogenic hormone in the body and exerts many
cardiovascular protective effects. Via three receptors known to date, including estrogen …

Interactions of isoflavones and other plant derived estrogens with estrogen receptors for prevention and treatment of breast cancer—considerations concerning related …

G Leclercq, Y Jacquot - The Journal of steroid biochemistry and molecular …, 2014 - Elsevier
Phytoestrogens are natural endocrine disruptors that interfere with estrogenic pathways.
They insert directly within the hormone-binding domain of ERα and β, with a preference for …

Promising perspectives of the antiproliferative GPER inverse agonist ERα17p in breast cancer

M Kampa, R Lappano, F Grande, B Rizzuti… - Cells, 2023 - mdpi.com
The estrogen receptor α (ERα) corresponds to a large platform in charge of the recruitment
of a panel of molecules, including steroids and related heterocyclic derivatives …

Deciphering of a putative GPER recognition domain in ERα and ERα36

A Acramel, Y Jacquot - Frontiers in Endocrinology, 2022 - frontiersin.org
Twenty-five years ago, a class A (rhodopsin-like) G protein-coupled receptor (GPCR) was
reported to participate in the rapid physiological responses to the mammalian steroid …

Calmodulin lobes facilitate dimerization and activation of estrogen receptor-α

Z Li, Y Zhang, AC Hedman, JB Ames… - Journal of Biological …, 2017 - ASBMB
Estrogen receptor α (ER-α) is a nuclear hormone receptor that controls selected genes,
thereby regulating proliferation and differentiation of target tissues, such as breast. Gene …

Concentration‐dependent and surface‐assisted self‐assembly properties of a bioactive estrogen receptor α‐derived peptide

FS Ruggeri, C Byrne, L Khemtemourian… - Journal of Peptide …, 2015 - Wiley Online Library
We have synthesized a 17‐mer peptide (ERα17p) that is issued from the hinge region of the
estrogen receptor α and which activates the proliferation of breast carcinoma cells in steroid …

The sequence Pro295–Thr311 of the hinge region of oestrogen receptor α is involved in ERK1/2 activation via GPR30 in leiomyoma cells

D Leiber, F Burlina, C Byrne, P Robin… - Biochemical …, 2015 - portlandpress.com
The ERα (oestrogen receptor α)-derived peptide ERα17p activates rapid signalling events in
breast carcinoma cells under steroid-deprived conditions. In the present study, we …

A β-turn motif in the steroid hormone receptor's ligand-binding domains interacts with the peptidyl-prolyl isomerase (PPIase) catalytic site of the immunophilin FKBP52

C Byrne, MA Henen, M Belnou, FX Cantrelle… - Biochemistry, 2016 - ACS Publications
The immunophilin FKBP52 interacts with nuclear steroid hormone receptors. Studying the
crystal structure of human estrogen receptor α (hERα) and using nuclear magnetic …

Promising perspectives of the antiproliferative GPER inverse agonist ERa17p in breast cancer

M Kampa, R Lappano, M Maggiolini, B Rizzuti… - 2023 - zaguan.unizar.es
The estrogen receptor α (ERα) corresponds to a large platform in charge of the recruitment
of a panel of molecules, including steroids and related heterocyclic derivatives …

Binding of calmodulin changes the calcineurin regulatory region to a less dynamic conformation

C Fu, J Zhang, Y Zheng, H Xu, S Yu - International journal of biological …, 2015 - Elsevier
Calcineurin (CN) is a Ca 2+/calmodulin (CaM) activated serine/threonine phosphatase, and
its regulatory region (CNRR) plays a critical role in the coupling of Ca 2+ signals to cellular …