Incipient and subclinical tuberculosis: a clinical review of early stages and progression of infection

PK Drain, KL Bajema, D Dowdy, K Dheda… - Clinical microbiology …, 2018 - Am Soc Microbiol
Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Tuberculous meningitis

RJ Wilkinson, U Rohlwink, UK Misra… - Nature reviews …, 2017 - nature.com
Tuberculosis remains a global health problem, with an estimated 10.4 million cases and 1.8
million deaths resulting from the disease in 2015. The most lethal and disabling form of …

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

D Stucki, D Brites, L Jeljeli, M Coscolla, Q Liu… - Nature …, 2016 - nature.com
Generalist and specialist species differ in the breadth of their ecological niches. Little is
known about the niche width of obligate human pathogens. Here we analyzed a global …

A robust SNP barcode for typing Mycobacterium tuberculosis complex strains

F Coll, R McNerney, JA Guerra-Assunção… - Nature …, 2014 - nature.com
Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an
important factor in pathogenesis that may affect virulence, transmissibility, host response …

The immune response in tuberculosis

A O'Garra, PS Redford, FW McNab… - Annual review of …, 2013 - annualreviews.org
There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

[HTML][HTML] Consequences of genomic diversity in Mycobacterium tuberculosis

M Coscolla, S Gagneux - Seminars in immunology, 2014 - Elsevier
The causative agent of human tuberculosis, Mycobacterium tuberculosis complex (MTBC),
comprises seven phylogenetically distinct lineages associated with different geographical …

Tuberculous meningitis: more questions, still too few answers

GE Thwaites, R van Toorn, J Schoeman - The Lancet Neurology, 2013 - thelancet.com
Tuberculous meningitis is especially common in young children and people with untreated
HIV infection, and it kills or disables roughly half of everyone affected. Childhood disease …

Co‐evolution of Mycobacterium tuberculosis and Homo sapiens

D Brites, S Gagneux - Immunological reviews, 2015 - Wiley Online Library
The causative agent of human tuberculosis (TB), M ycobacterium tuberculosis, is an obligate
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …

Human genetic susceptibility to infectious disease

SJ Chapman, AVS Hill - Nature Reviews Genetics, 2012 - nature.com
Recent genome-wide studies have reported novel associations between common
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …

Innate Immune Recognition of Mycobacterium tuberculosis

J Kleinnijenhuis, M Oosting… - Journal of …, 2011 - Wiley Online Library
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem,
with 10 million new cases diagnosed each year. Innate immunity plays an important role in …