Copper and zinc dysregulation in Alzheimer's disease
Alzheimer's disease (AD) is one of the most common forms of dementia. Despite a wealth of
knowledge on the molecular mechanisms involved in AD, current treatments have mainly …
knowledge on the molecular mechanisms involved in AD, current treatments have mainly …
[HTML][HTML] The redox chemistry of the Alzheimer's disease amyloid β peptide
DG Smith, R Cappai, KJ Barnham - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
There is a growing body of evidence to support a role for oxidative stress in Alzheimer's
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …
Metals and Alzheimer's disease: how far have we come in the clinic?
It is estimated that by the year 2050 there will be more than 1.5 billion people globally over
the age of 65 years. Aging is associated with changes to a number of different cellular …
the age of 65 years. Aging is associated with changes to a number of different cellular …
The role of metals in neurodegenerative processes: aluminum, manganese, and zinc
P Zatta, R Lucchini, SJ van Rensburg, A Taylor - Brain research bulletin, 2003 - Elsevier
Until the last decade, little attention was given by the neuroscience community to the
neurometabolism of metals. However, the neurobiology of heavy metals is now receiving …
neurometabolism of metals. However, the neurobiology of heavy metals is now receiving …
Zinc takes the center stage: its paradoxical role in Alzheimer's disease
MP Cuajungco, KY Fagét - Brain Research Reviews, 2003 - Elsevier
There is compelling evidence that the etiology of Alzheimer's disease (AD) involves
characteristic amyloid-β (Aβ) deposition, oxidative stress, and anomalous metal–Aβ protein …
characteristic amyloid-β (Aβ) deposition, oxidative stress, and anomalous metal–Aβ protein …
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging
H Atamna, DW Killilea, AN Killilea… - Proceedings of the …, 2002 - National Acad Sciences
Heme, a major functional form of iron in the cell, is synthesized in the mitochondria by
ferrochelatase inserting ferrous iron into protoporphyrin IX. Heme deficiency was induced …
ferrochelatase inserting ferrous iron into protoporphyrin IX. Heme deficiency was induced …
B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: a systematic review
AD Dangour, PJ Whitehouse, K Rafferty… - Journal of …, 2010 - content.iospress.com
The increasing worldwide prevalence of dementia is a major public health concern. Findings
from some epidemiological studies suggest that diet and nutrition may be important …
from some epidemiological studies suggest that diet and nutrition may be important …
[HTML][HTML] Alzheimer's disease, β-amyloid protein and zinc
Alzheimer's disease (AD) is characterized by amyloid deposits within the neocortical
parenchyma and the cerebrovasculature. The main component of these predominantly …
parenchyma and the cerebrovasculature. The main component of these predominantly …
Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease
Mitochondrial decay due to oxidative damage is a contributor to brain aging and age-related
neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease …
neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease …
Zinc Therapy in early Alzheimer's disease: Safety and potential therapeutic efficacy
Zinc therapy is normally utilized for treatment of Wilson disease (WD), an inherited condition
that is characterized by increased levels of non-ceruloplasmin bound ('free') copper in serum …
that is characterized by increased levels of non-ceruloplasmin bound ('free') copper in serum …