Copper and zinc dysregulation in Alzheimer's disease

SL Sensi, A Granzotto, M Siotto, R Squitti - Trends in Pharmacological …, 2018 - cell.com
Alzheimer's disease (AD) is one of the most common forms of dementia. Despite a wealth of
knowledge on the molecular mechanisms involved in AD, current treatments have mainly …

[HTML][HTML] The redox chemistry of the Alzheimer's disease amyloid β peptide

DG Smith, R Cappai, KJ Barnham - Biochimica et Biophysica Acta (BBA) …, 2007 - Elsevier
There is a growing body of evidence to support a role for oxidative stress in Alzheimer's
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …

Metals and Alzheimer's disease: how far have we come in the clinic?

PA Adlard, AI Bush - Journal of Alzheimer's Disease, 2018 - content.iospress.com
It is estimated that by the year 2050 there will be more than 1.5 billion people globally over
the age of 65 years. Aging is associated with changes to a number of different cellular …

The role of metals in neurodegenerative processes: aluminum, manganese, and zinc

P Zatta, R Lucchini, SJ van Rensburg, A Taylor - Brain research bulletin, 2003 - Elsevier
Until the last decade, little attention was given by the neuroscience community to the
neurometabolism of metals. However, the neurobiology of heavy metals is now receiving …

Zinc takes the center stage: its paradoxical role in Alzheimer's disease

MP Cuajungco, KY Fagét - Brain Research Reviews, 2003 - Elsevier
There is compelling evidence that the etiology of Alzheimer's disease (AD) involves
characteristic amyloid-β (Aβ) deposition, oxidative stress, and anomalous metal–Aβ protein …

Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging

H Atamna, DW Killilea, AN Killilea… - Proceedings of the …, 2002 - National Acad Sciences
Heme, a major functional form of iron in the cell, is synthesized in the mitochondria by
ferrochelatase inserting ferrous iron into protoporphyrin IX. Heme deficiency was induced …

B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: a systematic review

AD Dangour, PJ Whitehouse, K Rafferty… - Journal of …, 2010 - content.iospress.com
The increasing worldwide prevalence of dementia is a major public health concern. Findings
from some epidemiological studies suggest that diet and nutrition may be important …

[HTML][HTML] Alzheimer's disease, β-amyloid protein and zinc

X Huang, MP Cuajungco, CS Atwood, RD Moir… - The Journal of …, 2000 - Elsevier
Alzheimer's disease (AD) is characterized by amyloid deposits within the neocortical
parenchyma and the cerebrovasculature. The main component of these predominantly …

Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease

J Liu, BN Ames - Nutritional neuroscience, 2005 - Taylor & Francis
Mitochondrial decay due to oxidative damage is a contributor to brain aging and age-related
neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease …

Zinc Therapy in early Alzheimer's disease: Safety and potential therapeutic efficacy

R Squitti, A Pal, M Picozza, A Avan, M Ventriglia… - Biomolecules, 2020 - mdpi.com
Zinc therapy is normally utilized for treatment of Wilson disease (WD), an inherited condition
that is characterized by increased levels of non-ceruloplasmin bound ('free') copper in serum …