The survival rates of boys and men with cancer have increased due to advances in cancer
treatments; however, maintenance of quality of life, including fertility preservation, remains a …

In spite of generally accepted dogma that the total number of follicles and oocytes is
established in human ovaries during the fetal period of life rather than forming de novo in …

Historically, our understanding of molecular genetic aspects of human germ cell
development has been limited, at least in part due to inaccessibility of early stages of human …

The derivation of germ cells from human embryonic stem cells (hESCs) or human induced
pluripotent stem (hIPS) cells represents a desirable experimental model and potential …

Gamete failure-derived infertility affects millions of people worldwide; for many patients,
gamete donation by unrelated donors is the only available treatment. Embryonic stem cells …

Pluripotent cells can be derived from various types of somatic cells by nuclear
reprogramming using defined transcription factors. It is, however, unclear whether human …

The first histological observations about the origin of the precursors of gametes termed
primordial germ cells (PGCs) in extragonadal regions and their subsequent migration into …

BACKGROUND Investigating the mechanisms of human primordial germ cell (PGC) and
gamete development are important for understanding the causes of infertility and effects of …

Generation of functional spermatids from azoospermia patients is of unusual significance in
the treatment of male infertility. Here, we report an efficient approach to obtain human …

Recent studies have reported that induced pluripotent stem (iPS) cells from mice and
humans can differentiate into primordial germ cells. However, whether iPS cells are capable …