Macrophages play an essential role not only in mediating the first line of defense but also in
maintaining tissue homeostasis. In response to extrinsic factors derived from a given tissue …

Objective: To review the evidence for a genetic influence on the susceptibility to and
outcome from sepsis. Design: Literature review. Patients: Variety of adult and pediatric …

The lipidome of equine BALF cells has not been described. The objectives of this
prospective repeated-measures study were to explore the BALF cells' lipidome in horses …

Whereas decreased concentrations of surfactant protein (SP)-B are associated with lung
injury and respiratory distress, potential causal relationships between SP-B deficiency and …

Study Design: The role of antenatal inflammation in the induction of lung injury was explored
in a sheep model suitable for the study of lung development with respect to human …

Exacerbations are important events in the natural history of chronic obstructive pulmonary
disease (COPD). The higher the number of COPD exacerbations, the worse are the clinical …

Objective: Pulmonary surfactant protein (SP)-B plays a vital role in the formation and function
of surfactant in the lung. A genetic polymorphism (SP-B+ 1580) is postulated to result in …

Bronchopulmonary dysplasia (BPD), the most common chronic lung disease in infancy, is
influenced by a number of antenatal and postnatal risk factors and is mostly preceded by …

Introduction: The respiratory tract is an attractive target for the delivery of vaccine antigens.
Potential advantages of drug delivery by means of the pulmonary route include accessibility …

We previously showed that surfactant inhibits the synthesis of type IIA secretory
phospholipase A2 (sPLA2-IIA) by alveolar macrophages. These cells have been identified …