HDAC6 as privileged target in drug discovery: A perspective
Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …
physiological functions. Besides histone modification, largely due to its cytoplasmic …
The RUNX family: developmental regulators in cancer
Y Ito, SC Bae, LSH Chuang - Nature Reviews Cancer, 2015 - nature.com
RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …
regulators of development. They are frequently deregulated in human cancers, indicating a …
[PDF][PDF] HDAC and HDAC inhibitor: from cancer to cardiovascular diseases
S Yoon, GH Eom - Chonnam medical journal, 2016 - synapse.koreamed.org
Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail,
chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also …
chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also …
Histone deacetylase inhibitors: molecular mechanisms of action
WS Xu, RB Parmigiani, PA Marks - Oncogene, 2007 - nature.com
This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors
(HDACi), a group of recently discovered 'targeted'anticancer agents. There are 18 HDACs …
(HDACi), a group of recently discovered 'targeted'anticancer agents. There are 18 HDACs …
Histone deacetylases and cancer
MA Glozak, E Seto - Oncogene, 2007 - nature.com
Histone deacetylases (HDACs) regulate the expression and activity of numerous proteins
involved in both cancer initiation and cancer progression. By removal of acetyl groups from …
involved in both cancer initiation and cancer progression. By removal of acetyl groups from …
Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes
Y Li, D Shin, SH Kwon - The FEBS journal, 2013 - Wiley Online Library
Histone deacetylase (HDAC) 6 is the best‐characterized class II b deacetylase that
regulates many important biological processes via the formation of complexes with its …
regulates many important biological processes via the formation of complexes with its …
[HTML][HTML] Signaling and transcriptional regulation in osteoblast commitment and differentiation
W Huang, S Yang, J Shao, YP Li - Frontiers in bioscience: a journal …, 2007 - ncbi.nlm.nih.gov
The major event that triggers osteogenesis is the transition of mesenchymal stem cells into
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …
Lost in transcription: p21 repression, mechanisms, and consequences
AL Gartel, SK Radhakrishnan - Cancer research, 2005 - AACR
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 is a major player in cell cycle control
and it is mainly regulated at the transcriptional level. Whereas induction of p21 …
and it is mainly regulated at the transcriptional level. Whereas induction of p21 …
Transcriptional regulatory cascades in Runx2-dependent bone development
The development of the musculoskeletal system is a complex process that involves very
precise control of bone formation and growth as well as remodeling during postnatal life …
precise control of bone formation and growth as well as remodeling during postnatal life …
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally
Y Zhang, SH Kwon, T Yamaguchi… - … and cellular biology, 2008 - Taylor & Francis
Posttranslational modifications play important roles in regulating protein structure and
function. Histone deacetylase 6 (HDAC6) is a mostly cytoplasmic class II HDAC, which has a …
function. Histone deacetylase 6 (HDAC6) is a mostly cytoplasmic class II HDAC, which has a …