Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly
comprises the actin microfilaments, microtubules, and intermediate filaments. During …

The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of
receptor interacting protein 3 (RIP3) in tumor necrosis factor-α (TNF)-induced necrosis (also …

Directed cell migration is critical for embryogenesis and organ development, wound healing
and the immune response. Microtubules are dynamic polymers that control directional …

Mitochondrial division, essential for survival in mammals, is enhanced by an inter-organellar
process involving ER tubules encircling and constricting mitochondria. The force for …

The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …

Migration is a polarized cellular process that opposes a protrusive front edge to a retracting
trailing edge. From the front to the rear, actin-mediated forces sequentially promote cell …