The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …

Cholangiocarcinoma (CCA) is a rare disease characterized by malignant cells derived from
the epithelial cells of the biliary duct system. Despite extensive treatments, the prognosis for …

The potent cytotoxic property of Vγ2Vδ2 T cells makes them attractive for adoptive T cell
transfer therapy. The transfusing of the expanded Vγ2Vδ2 T cells into cancer patients shows …

Multidrug-resistant tuberculosis (MDR-TB) is a refractory disease with high mortality rate due
to no or few choices of antibiotics. Adjunctive immunotherapy may help improve treatment …

Co-activation signal that induces/sustains pleiotropic effector functions of antigen-specific γδ
T cells remains unknown. Here, Mycobacteria tuberculosis (Mtb) tuberculin administration …

Vγ2Vδ2 T cell-based immunotherapy has benefited some patients in clinical trials, but the
overall efficacy is low for solid tumor patients. In this study, a bispecific antibody against both …

Abstract γδT cells are unconventional T cells particularly abundant in mucosal tissues that
play an important role in tissue surveillance, homeostasis, and cancer. γδT cells recognize …

It remains undefined whether a subset of CD4+ T cells can function as fast-acting cells to
control Mycobacterium tuberculosis (Mtb) infection. Here we show that the primary CD4+ …

Background Mycobacterium tuberculosis heat-resistant antigen (Mtb-HAg) is a peptide
antigen released from the mycobacterial cytoplasm into the supernatant of Mycobacterium …