The establishment of precise neuronal cell morphology provides the foundation for all
aspects of neurobiology. During development, axons emerge from cell bodies after an initial …

Highlights•Convergence between axon regeneration ability and abnormal synaptic structure
and function.•Axon regeneration, neuronal circuit assembly and recovery of functions in the …

Injuries to the adult CNS often result in permanent disabilities because neurons lose the
ability to regenerate their axon during development. Here, whole transcriptome sequencing …

Individuals with neurofibromatosis type 1 (NF1) develop abnormalities of both neuronal and
glial cell lineages, suggesting that the NF1 protein neurofibromin is an essential regulator of …

In the adult mammalian CNS, the growth inhibitors oligodendrocyte-myelin glycoprotein
(OMgp) and the reticulon RTN4 (Nogo) are broadly expressed in oligodendrocytes and …

Background: Neurogenesis requires neural progenitor cell (NPC) proliferation, neuronal
migration, and differentiation. During embryonic development, neurons are generated in …

Individuals with the neurofibromatosis type 1 (NF1) inherited cancer syndrome exhibit
neuronal dysfunction that predominantly affects the CNS. In this report, we demonstrate a …

The repair of nerve gap injuries longer than 3 cm is limited by the need to sacrifice donor
tissue and the morbidity associated with the autograft gold standard, while decellularized …

Axons in the adult mammalian central nervous system (CNS) fail to regenerate inside out
due to intrinsic and extrinsic neuronal determinants. During CNS development, axon growth …

Children with the neurofibromatosis-1 (NF1) cancer predisposition syndrome exhibit
numerous clinical problems that reflect defective central nervous system (CNS) neuronal …